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Progresses on the study of structural and functional MRI changes of cerebellum in patients with temporal lobe epilepsy
LI Jiachen  LIU Guangyao  HUANG Wenjing  LI Min  CHENG Xiu  LI Jie  ZHANG Jing 

Cite this article as: Li JC, Liu GY, Huang WJ, et al. Progresses on the study of structural and functional MRI changes of cerebellum in patients with temporal lobe epilepsy[J]. Chin J Magn Reson Imaging, 2022, 13(4): 150-153, 165. DOI:10.12015/issn.1674-8034.2022.04.033.


[Abstract] The pathogenesis of epilepsy is very complex and still not fully understood. The well-known mechanism is the imbalance of excitation and inhibition in the central nervous system. With the development of MRI technology, more and more studies use advanced imaging technology to explore the mechanism of epilepsy from the perspective of cerebellar structural and functional changes. Current studies have found changes in the structure and function of the cerebellum in patients with different types of epilepsy. This paper summarizes the previous studies on the abnormal changes in the structure and function of the cerebellum in patients with temporal lobe epilepsy (TLE). Changes in white matter pathways and cerebellum-hippocampal connections between the brains, functional connectivity impairments between the cerebellum and some cerebral regions, and the role of the cerebellum in networks such as the alertness network and the default mode network. The cerebellum is also associated with cognitive, executive control, language, and memory impairments in patients with TLE. There are also abnormalities in cerebellar perfusion and metabolism. The use of advanced MRI technology is expected to further clarify the role of the cerebellum in TLE, reveal the pathophysiological mechanism of TLE, and make the cerebellum a potential therapeutic target for TLE in the future.
[Keywords] temporal lobe epilepsy；cerebellum；magnetic resonance imaging；brain structure；brain function

LI Jiachen1, 2   LIU Guangyao1   HUANG Wenjing1, 2   LI Min1   CHENG Xiu1, 2   LI Jie1, 2   ZHANG Jing1*  

1 Department of Nuclear Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China

2 Second Clinical School, Lanzhou University, Lanzhou 730030, China

Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82160326).
Received  2021-12-20
Accepted  2022-03-25
DOI: 10.12015/issn.1674-8034.2022.04.033
Cite this article as: Li JC, Liu GY, Huang WJ, et al. Progresses on the study of structural and functional MRI changes of cerebellum in patients with temporal lobe epilepsy[J]. Chin J Magn Reson Imaging, 2022, 13(4): 150-153, 165. DOI:10.12015/issn.1674-8034.2022.04.033.

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