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Probe of the central mechanism of adult patients with amblyopia based on rs-fMRI technique
WANG Yige  ZHAO Tong  ZHANG Xiangfei  LIU Bing  YANG Aocai  LÜ Kuan  MA Guolin 

Cite this article as: Wang YG, Zhao T, Zhang XF, et al. Probe of the central mechanism of adult patients with amblyopia based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2022, 13(11): 12-16, 29. DOI:10.12015/issn.1674-8034.2022.11.003.


[Abstract] Objective To explore the central mechanism of adult patients with amblyopia by resting state-functional magnetic resonance imaging (rs-fMRI).Materials and Methods We recruited 21 adult patients with amblyopia and 22 healthy controls (HC) group matched with age, sex and education as subjects. Clinical data including best corrected visual acuity, stereopsis, self-rating anxiety and depression scale were performed. Meanwhile, rs-fMRI was collected and preprocessed with DPARSF software. The difference of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF) between the two groups and the correlation between ReHo, fALFF and clinical data in changed brain regions were analyzed.Results In all recruited adult patients with amblyopic, fALFF value of right superior temporal gyrus decreased, while fALFF of right angular gyrus increased (cluster level, P＜0.01). ReHo value of right fusiform gyrus and lingual gyrus of occipital lobe increased. What's more, fALFF of bilateral fusiform gyrus and left calcarine fissure in left-sided amblyopic patients significantly increased (cluster level, P＜0.05). ReHo of bilateral fusiform gyrus also increased (cluster level, P＜0.05). fALFF of right superior temporal gyrus decreased and right middle frontal gyrus increased in right-sided patients (cluster level, P＜0.01). These values in the differential brain regions did not correlate significantly with Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores.Conclusions In the central mechanism of adult patients with amblyopia, the activation and ReHo changes in occipital and temporal cortex may be involved in the functional compensation of visual information processing caused by visual impairment, which helps to further reveal the central mechanism of adult amblyopia.
[Keywords] amblyopia adults；resting state-magnetic resonance imaging；magnetic resonance imaging；regional homogeneity；fractional amplitude of low-frequency fluctuation

WANG Yige1, 2   ZHAO Tong3   ZHANG Xiangfei4   LIU Bing1, 2   YANG Aocai1, 2   LÜ Kuan2   MA Guolin2*  

1 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

2 Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

3 Department of Ophthalmology, China-Japan Friendship Hospital, Beijing 100029, China

4 Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China

Ma GL, E-mail: maguolin1007@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Key Research and Development Program of China (No. 2020YFC2003903, 2020YFC2007301); National Natural Science Foundation of China (No. 81971585, 82271953); Guangzhou Science and Technology Planning Project (No. 202103010001);Beijing Municipal Science and Technology Planning Project (No. Z211100003521009); Capital's Funds for Health Improvement and Research (No. 2020-2-4061).
Received  2022-07-05
Accepted  2022-11-14
DOI: 10.12015/issn.1674-8034.2022.11.003
Cite this article as: Wang YG, Zhao T, Zhang XF, et al. Probe of the central mechanism of adult patients with amblyopia based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2022, 13(11): 12-16, 29. DOI:10.12015/issn.1674-8034.2022.11.003.

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