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• Clinical Article •
Application value of FOCUS diffusion weighted imaging in the diagnosis of microprolactinomas
WANG Minyang  YU Ying  YAN Linfeng  HAN Yu  YANG Yang  LIANG Shouheng  WANG Yuyao  CUI Guangbin 

Cite this article as: Wang MY, Yu Y, Yan LF, et al. Application value of FOCUS diffusion weighted imaging in the diagnosis of microprolactinomas[J]. Chin J Magn Reson Imaging, 2022, 13(11): 60-65. DOI:10.12015/issn.1674-8034.2022.11.011.


[Abstract] Objective To explore the diagnostic value of FOCUS (field of view optimized and constrained undistorted single-shot) diffusion weighted imaging (DWI) in microprolactinomas.Materials and Methods This retrospective study included 32 patients with microprolactinomas and 24 patients with hyperprolactinemia. The images of non-enhanced, dynamic enhanced, and FOCUS DWI were analyzed, and the apparent diffusion coefficient (ADC) values were measured in the FOCUS DWI sequences. The ADC values of the lesion and the adjacent uninvolved pituitary in microprolactinomas cases and the mean ADC values of hyperprolactinemia group were compared. ANOVA with randomized block design was used to compare the ADC values of the left, middle and right anterior pituitary in hyperprolactinemia group. The receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic efficacy of the ADC ratio (rADC) between the lesion and the adjacent uninvolved pituitary in microprolactinomas cases.Results The ADC values of the lesions in microprolactinomas group were lower than that of the adjacent uninvolved pituitary region and the mean ADC values of anterior pituitary gland in hyperprolactinemia group (P＜0.001), and no significant difference were found between the latter two (P=0.120). In hyperprolactinemia group, the ADC values of middle anterior pituitary were significantly higher than that of left and right anterior pituitary (Pright=0.001, Pleft=0.012). No significant difference was found between the ADC values in left and right anterior pituitary (P=1.000). The area under ROC curve in the diagnosis of microprolactinomas by rADC was 0.793.Conclusions FOCUS DWI can help to distinguish microprolactinomas from simple hyperprolactinemia pituitary, and it can be considered as an auxiliary diagnosis means of microprolactinomas, which could provide objective evidence for clinicians to make the best treatment plan.
[Keywords] microprolactinomas；hyperprolactinemia；saddle area；magnetic resonance imaging；diffusion weighted imaging；apparent diffusion coefficient

WANG Minyang1, 2   YU Ying2   YAN Linfeng2   HAN Yu2   YANG Yang2   LIANG Shouheng2   WANG Yuyao2   CUI Guangbin1, 2*  

1 Faculty of Medical Technology, Shannxi University of Chinese Medicine, Xianyang 712046, China

2 Department of Radiology, Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

Cui GB, E-mail: cgbtd@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development Plan of Shaanxi Province (No. 2019ZDLSF02-07).
Received  2022-08-13
Accepted  2022-11-07
DOI: 10.12015/issn.1674-8034.2022.11.011
Cite this article as: Wang MY, Yu Y, Yan LF, et al. Application value of FOCUS diffusion weighted imaging in the diagnosis of microprolactinomas[J]. Chin J Magn Reson Imaging, 2022, 13(11): 60-65. DOI:10.12015/issn.1674-8034.2022.11.011.

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