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• Clinical Article •
Quantitative susceptibility mapping of substantia nigra in the diagnosis of Parkinson's disease: A Meta analysis
WU Mingzhen  LUAN Jixin  ZHANG Chuanchen  XU Yongzhou  HE Chengbing  WANG Yu  ZHANG Ruxin 

Cite this article as: WU M Z, LUAN J X, ZHANG C C, et al. Quantitative susceptibility mapping of substantia nigra in the diagnosis of Parkinson's disease: A Meta analysis[J]. Chin J Magn Reson Imaging, 2023, 14(2): 6-11. DOI:10.12015/issn.1674-8034.2023.02.002.


[Abstract] Objective To systematically evaluate the diagnostic performance of quantitative susceptibility mapping (QSM) in the substantia nigra for Parkinson's disease (PD) using Meta-analysis.Materials and Methods A systematic literature search in the PubMed, EMBASE, the Cochrane Library, Web of Science, CNKI, Wanfang Data, China Biology Medicine disc (CBMdisc) and VIP databases was performed for studies about QSM in the diagnosis of PD from inception to May 2022. Two researchers independently screened literature, extracted data, and assessed the risk of bias of the included studies. RevMan 5.0 and Stata 17.0 software were used for Meta-analysis.Results A total of 16 studies including 702 patients with PD and 497 healthy control participants were enrolled in this Meta-analysis. QSM showed a pooled sensitivity (Sen), specificity (Spe), positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) with their 95% confidence intervals (CI) of 0.87 (0.83-0.90), 0.77 (0.69-0.84), 3.84 (2.74-5.39), 0.17 (0.12-0.22) and 23.19 (13.41-40.07). The area under the curve (AUC) was 0.90 (0.87-0.93). According to subgroup analysis, the AUC of a specific measurement of substantial nigra pars compacta [AUC＝0.90 (95% CI: 0.87-0.92)], slice thickness ≤1 mm [AUC＝0.93 (95% CI: 0.91-0.95)] is superior than measurement of the whole substantial pars [AUC＝0.81 (95% CI: 0.77-0.84)], slice thickness＞1 mm [AUC＝0.88 (95% CI: 0.85-0.91)]. Deek's funnel plot showed no publication bias (P=0.24).Conclusions The current evidence shows that QSM had a favorable diagnostic performance in diagnosing PD, especially in a specific measurement of substantial nigra or slice thickness ≤1 mm, which provides imaging basis for early diagnosis and follow-up of PD.
[Keywords] Parkinson's disease；substantia nigra；quantitative susceptibility mapping；Meta analysis；magnetic resonance imaging

WU Mingzhen1   LUAN Jixin2   ZHANG Chuanchen1*   XU Yongzhou3   HE Chengbing1   WANG Yu1   ZHANG Ruxin1  

1 Department of MR, Liaocheng People's Hospital, Liaocheng 252000, China

2 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

3 Philips (China) Investment Co, Ltd., Shanghai 200072, China

*Correspondence to: Zhang CC, E-mail: Zhangchuanchen666@163.com

Conflicts of interest   None.

Received  2022-10-09
Accepted  2023-01-12
DOI: 10.12015/issn.1674-8034.2023.02.002
Cite this article as: WU M Z, LUAN J X, ZHANG C C, et al. Quantitative susceptibility mapping of substantia nigra in the diagnosis of Parkinson's disease: A Meta analysis[J]. Chin J Magn Reson Imaging, 2023, 14(2): 6-11. DOI:10.12015/issn.1674-8034.2023.02.002.

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