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• Clinical Article •
Functional connectivity of the primary visual cortex in patients with comitant exotropia
CHEN Wanyun  JIN Han 

Cite this article as: CHEN W Y, JIN H. Functional connectivity of the primary visual cortex in patients with comitant exotropia[J]. Chin J Magn Reson Imaging, 2023, 14(2): 33-36, 102. DOI:10.12015/issn.1674-8034.2023.02.006.


[Abstract] Objective Based on the resting state functional connection (RSFC) method, this study studied the functional connectivity of primary visual cortex (V1) in patients with concomitant exotropia (CE).Materials and Methods The clinical data of 24 CE patients (CE group) and 24 healthy controls (HC group) matched for sex and age with the CE group were retrospectively analyzed, patients in both groups were scanned by 3.0 T MRI. The functional connection (FC) of the V1 of the two groups were analyzed by RSFC method, and the differences of FC of V1 between the two groups were compared by double sample t test.Results Compared with the healthy control group, there was no significant difference in sex and age between the two groups (P＞0.05). The FC between bilateral V1 and Cerebelum_7b_L was enhanced in CE group (GRF correction, voxel level P＜0.001, cluster level P＜0.05).Conclusions The enhancement of FC between bilateral V1 and the lower cerebellum in patients with CE may provide a reference for the neuropathological mechanism of binocular visual impairment in patients with CE.
[Keywords] comitant exotropia；magnetic resonance imaging；resting state functional magnetic resonance imaging；functional connectivity；primary visual cortex；spontaneous activity

CHEN Wanyun1, 2   JIN Han2*  

1 Medical College of Nanchang University, Nanchang 330000, China

2 Department of Ophthalmology, Jiangxi Provincial People's Hospital (the First Affiliated Hospital of Nanchang Medical College), Nanchang 330000, China

*Correspondence to: Jin H, E-mail: jinhan0791@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Jiangxi Province (No. 20212BAB216058).
Received  2022-07-08
Accepted  2023-01-17
DOI: 10.12015/issn.1674-8034.2023.02.006
Cite this article as: CHEN W Y, JIN H. Functional connectivity of the primary visual cortex in patients with comitant exotropia[J]. Chin J Magn Reson Imaging, 2023, 14(2): 33-36, 102. DOI:10.12015/issn.1674-8034.2023.02.006.

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