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• Clinical Article •
Application of 3.0 T MRI in evaluation of nipple areola complex invasion in breast cancer patients
WEN Jie  WANG Meng  REN Ya  GUAN Jian  LIU Zhou  XIANG Lu  LUO Dehong 

Cite this article as: WEN J, WANG M, REN Y, et al. Application of 3.0 T MRI in evaluation of nipple areola complex invasion in breast cancer patients[J]. Chin J Magn Reson Imaging, 2023, 14(2): 44-49. DOI:10.12015/issn.1674-8034.2023.02.008.


[Abstract] Objective Preoperative 3.0 T MRI was used to assess the value of nipple areola complex invasion in breast cancer patients.Materials and Methods Patients with primary operable breast cancer who underwent preoperative MRI examination and underwent surgical treatment from November 2019 to January 2022 were collected. The accuracy of MRI signs in judging the invasion of nipple areola complex (NAC) was evaluated by comparing the results of preoperative MRI and postoperative histopathology.Results There were 179 breast cancer patients, 40 were NAC positive groups, 139 were NAC negative groups. On the breast MRI the distance from tumor to nipple ≤0.75 cm, nipple retraction, tumor-to-NAC continuous enhancement sign, NAC skin thickening and unilateral nipple enhancement were helpful for the diagnosis of NAC invasion (P＜0.05). By plotting receiver operator characteristic curve, the distance between the tumor and the nipple was ≤0.75 cm, and the area under the curve for the diagnosis of NAC invasion was higher than the last four signs (0.862 vs. 0.739, 0.800, 0.696, 0.711).Conclusions The MRI features of breast (the distance from tumor to nipple, nipple retraction, tumor-to-NAC continuous enhancement sign, NAC skin thickening and unilateral nipple enhancement) provide an effective method for non-invasive preoperative evaluation of the invasion of the nipple areola complex in breast cancer, which can provide more valuable information before breast cancer surgery.
[Keywords] breast cancer；nipple areola complex；tumor nipple distance；continuous enhancement sign；magnetic resonance imaging

WEN Jie1   WANG Meng1   REN Ya1   GUAN Jian2   LIU Zhou1   XIANG Lu1   LUO Dehong1, 3*  

1 Department of Radiology, Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China

2 Department of Pathology, Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China

3 Department of Radiology, Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

*Correspondence to: Luo DH, E-mail: cjr.luodehong@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Shenzhen High-level Hospital Construction Fund; Scientific Research Project of National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（No. E010321005）.
Received  2022-09-07
Accepted  2023-01-12
DOI: 10.12015/issn.1674-8034.2023.02.008
Cite this article as: WEN J, WANG M, REN Y, et al. Application of 3.0 T MRI in evaluation of nipple areola complex invasion in breast cancer patients[J]. Chin J Magn Reson Imaging, 2023, 14(2): 44-49. DOI:10.12015/issn.1674-8034.2023.02.008.

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