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• Clinical Article •
Functional MRI evaluation on linguistic center in patients with expressive aphasia after cerebral infarction
HE Ya-na  ZHANG Quan  ZHANG Yun-ting  SONG Ming  ZHU Xiao-dong  CHEN Jing  YI Hui-ming  JIANG Tian-zi 

DOI:10.3969/j.issn.1674-8034.2010.01.004.


[Abstract] Objective: To evaluate the brain activation in patients with expressive aphasia after cerebral infarction.Materials and Methods: Fifteen patients suffering from expressive aphasia after cerebral infarction and 15 normal middle-old aged subjects were recruited in this study. All patients and subjects received block-designed category-member generation task fMRI. SPM2 software was used to process fMRI data. Intra- and inter-group analysis was performed to obtain activated mapping in of two groups and different mapping between two groups. MNI coordinate and activated intensity of the brain regions were recorded.Results: Ten male patients and ten male controls were selected after head motion and machine noise had been ruled out. Activated regions of the control group included Broca’s area, right Broca’s homologue area, supplement motor area (SMA), left anterior insula, left superior temporal gyrus and left precentral gyrus. Activated regions of the patient group included left middle frontal gyrus, postcentral gyrus, inferior parietal lobule, precuneus lobe, right inferior frontal gyrus, bilaterial precentral gyrus, insula, thalamas,striatum, SMA and cerebellum. When contrast to the patients group, only the posterior part of left inferior frontal gyrus showed activation in control group. There was no significant activation when patients group contrast to control group.Conclusion: Compared with normal middle-old aged controls, the activation level of the posterior part of left inferior frontal gyrus (Broca's area) declined or disappeared in patients with expressive aphasia after cerebral infarction, which suggest that the damage to the Broca’s area has led to the occurrence of expressive aphasia.
[Keywords] Magnetic resonance imaging, functional；Brain infarction；Aphasia, broca

HE Ya-na Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

ZHANG Quan Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

ZHANG Yun-ting* Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

SONG Ming The National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

ZHU Xiao-dong Department of Neurosciences, Tianjin Medical University General Hospital, Tianjin 300052, China

CHEN Jing Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

YI Hui-ming Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

JIANG Tian-zi The National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

*Correspondence to: Zhang YT, E-mail: cjr.zhangyunting@vip.163.com

Conflicts of interest   None.

Received  2009-12-17
Accepted  2010-01-14
DOI: 10.3969/j.issn.1674-8034.2010.01.004
DOI:10.3969/j.issn.1674-8034.2010.01.004.

[1]
Wade D, Hewer R, David R, et al. Aphasia after stroke: Natural history and associated deficits. J Neurol Neurosurg Psychiatry, 1986, 49(1):11-16.
[2]
Dietmar C, Haughton K. Mapping functionally related regions of brain with functional connectivity MR imaging. AJNR Am J Neuroradial, 2000, 21(9): 1636-1644.
[3]
Binder J, Frost J, Hammeke T, et a1. Human brain language areas identified by functional magnetic resonance imaging. J Neuroimaging, 1997, 17(1): 353-362.
[4]
Petersen S, Fox P, Posner M, et al. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 1988, 331(6157): 585-589.
[5]
Cao Y, Vikingstad EM, George KP, et al. Cortical language activation in stroke patients recovering from aphasia with functional MRI. Stroke, 1999, 30(11): 2331-2340.
[6]
Khateb A, Martory M, Annoni J, et a1. Transient crossed aphasia evidenced by functional brain imagery. Neuroreport, 2004, 15(5): 785-790.
[7]
Dronkers N. A new brain region for coordinating speech articulation. Nature, 1996, 384(6605): 159-161.
[8]
Alario F, Chainay H, Lehericy S, et al. The role of the supplementary motor area (SMA) in word production. Brain Res, 2006, 1076(1): 129-143.
[9]
Karbe H, Thiel A, Weber-Luxenburger G, et al. Brain plasticity in poststroke aphasia: what is the contribution of the right hemisphere. Brain Lang, 1998, 64(2): 215-230.
[10]
Paulesu E, Frith C, Frackowiak R. The neural correlates of the verbal component of working memory. Nature, 1993, 362(6418): 342-345.
[11]
Allison J, Meador K, Loring D, et al. Functional MRI cerebral activation and deactivation during finger movement. Neurology, 2000, 54(1): 135-137.
[12]
Ji Q, Zheng KE, Chen FJ, et al. Functional MRI evaluation on linguistic center of auditory function in normal volunteers and the location of brain neoplasms. Chin J Neurosurg, 2007, 23(5):335.
[13]
Gil Robles S, Gatignol P, Capelle L, et a1. The role of dominant striatum in language: a study using intraopemtive electrical stimulations. J Neurol Neurosurg Psychiatry, 2005, 76(7): 940-946.
[14]
Jie B, Zhao XH, Yang ZY, et al. The language function of cerebellum: A fMRI study. J Tongji Univ (Med Sci), 2005, 26(6): 22-25.
[15]
Riecker A, Mathiak K, Wildgruber D, et al. fMRI reveals two distinct cerebral networks subserving speech motor control. Neurology, 2005, 64(4): 700-706.
[16]
Ino T, Tokumoto K, Usami K. Longitudinal fMRI study of reading in a patient with letter-by-letter reading. Cortex, 2008, 44(7): 773-781.
[17]
Carmichael S, Chesselet M. Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult. J Neurosci, 2002, 22(14), 6062-6070.
[18]
Wise R. Language systems in normal and aphasic human subjects: functional imaging studies and inferences from an imal studies. Br Med Bull, 2003, 65(1): 95-119.
[19]
Crosson B. Models of subcortical functions in language: current status. J Neurolinguist, 1997, 10(4): 277-300.
[20]
Kraut M, Kremen S, Segal J, et al. Object activation from features in the semantic system. J Cogn Neurosci, 2002, 14(1): 24-36.
[21]
Wallesch C. Symptomatology of subcortical aphasia. J Neurolinguist, 1997, 10(4): 267-275.

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