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• Clinical Article •
Investigation of brain motor functional connectivity in ischemic stroke patients after rehabilitative treatment with resting-state functional MRI
DENG xiao-xiang  JIANG Wen  WANG Jun  TANG Qi-yu  HUANG Rui-wang  ZHANG Yu-mei  AI Lin  DAI Jian-ping 

DOI:10.3969/j.issn.1674-8034.2010.01.005.


[Abstract] Objective: To investigate the change of brain motor functional connectivity in ischemic stroke patients after rehabilitative treatment with resting-state functional MRI(fMRI).Materials and Methods: Resting-state fMRI was employed on two sub-acute ischemic stroke patients before and after the rehabilitative treatment with functional electric stimulation (FES), and the difference of brain motor functional connectivity was analyzed.Results: After rehabilitative treatment, motor function of upper extremity was ameliorated, and functional connectivity of bilateral motor cortex was decreased. There was the correlation between behavioral improvement and connectivity decrease.Conclusion: The dependence of affected cerebral hemisphere on unaffected cerebral hemisphere was decreased after motor functional improvement of upper extremity.
[Keywords] Ischemic stroke；Magnetic resonance imaging, functional；Resting-state；Motor cortex；Electric stimulation；Rehabilitation

DENG xiao-xiang State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China

JIANG Wen Department of Radiology, Tiantan Hospital of Capital Medical University, Beijing 100050, China

WANG Jun State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China

TANG Qi-yu Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China

HUANG Rui-wang State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China

ZHANG Yu-mei Department of Neurology, Tiantan Hospital of Capital Medical University, Beijing 100050, China

AI Lin* Department of Radiology, Tiantan Hospital of Capital Medical University, Beijing 100050, China

DAI Jian-ping* Department of Radiology, Tiantan Hospital of Capital Medical University, Beijing 100050, China

*Correspondence to: Ai L, E-mail: ailin136@yahoo.com.cn; Dai JP, E-mail: djp_jmrm@126.com

Conflicts of interest   None.

Received  2010-01-11
Accepted  2010-01-15
DOI: 10.3969/j.issn.1674-8034.2010.01.005
DOI:10.3969/j.issn.1674-8034.2010.01.005.

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