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• Clinical Article •
Diffusion weighted MR imaging in differentiation of low grade gliomas
QIAN Yin-feng  YIN Min-min  YU Yong-qiang 

DOI:10.3969/j.issn.1674-8034.2010.01.007.


[Abstract] Objective: To assess the value of diffusion weighted imaging (DWI) in the differentiation of intracranial low grade gliomas.Materials and Methods: Twenty-one patients with pathologically proved low grade gliomas were divided into three groups: 9 astrocytomas (AC, grade II), 5 oligodendrogliomas (OD, grade II) and 7 oligodendroastrocytomas (OA, grade II). The apparent diffusion coefficient (ADC) and exponent diffusion coefficient (EDC) values in tumor solid part, peritumor edema and contralateral white matter of each tumor were measured, relative ADC (rADC) and relative EDC (rEDC) was calculated. Mean values of ADC, rADC, EDC and rEDC were analyzed among the three groups.Results: Mean ADC and rADC of tumor solid part were 1.12 and 1.52 for OD, 1.14 and 1.48 for OA, 1.93 and 2.38 for AC respectively. Mean EDC and rEDC of tumor solid part was 0.33 and 0.70 for OD, 0.32 and 0.71 for OA, 0.15 and 0.34 for AC, respectively. There was significant difference (P<0.01) between OD and AC, OA and AC in all parameters of tumor solid part. However, no significant difference was found between OD and OA in all parameters of tumor solid part. In peritumor edema, the difference was not significant among the three groups in all parameters.Conclusion: DWI may be helpful in differentiating OD and OA from AC, but not between OD and OA.
[Keywords] Magnetic resonance imaging, diffusion；Glioma, low grade

QIAN Yin-feng Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

YIN Min-min Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

YU Yong-qiang* Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

*Correspondence to: Yu YQ, E-mail: shenyx@ustc.edu.cn

Conflicts of interest   None.

Received  2010-01-04
Accepted  2010-01-15
DOI: 10.3969/j.issn.1674-8034.2010.01.007
DOI:10.3969/j.issn.1674-8034.2010.01.007.

[1]
Louis DN, Ohgaki H, Wiestler OD, et a1. The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neuropathol, 2007, 114(2): 97-109.
[2]
Ino Y, Betensky RA, Zlatescu MC, et a1. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res, 2001, 7(4): 839-845.
[3]
Helenius J, Soinne L, Perkio J, et al. Diffusion-weighted MR imaging in normal human brains in various age groups. AJNR Am J Neuroradiol, 2002, 23(2): 194-199.
[4]
Bulakbasi N, Guvenc I, Onguru O, et al. The added value of the apparent diffusion coefficient calculation to magnetic resonance imaging in the differentiation and grading of malignant brain tumors. J Comput Assist Tomogr, 2004, 28(6): 735-746.
[5]
Calli C, Kitis O, Yunten N, et a1. Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors. Eur J Radiol, 2006, 58(3): 394-403.
[6]
Stadlbaner A, Gansdandt O, Buslei R, et a1. Gliomas: histopathologic evaluation of changes in directionality and magnitude of water diffusion at diffusion-tensor MR imaging. Radiology, 2006, 240(3): 803-810.
[7]
Qiao GY, Gui QP, Wang FL. Histopathologic and molecular biological progress of oligodendroglioma. Acad J PLA Postgraduate Med School, 2006,27(2):158-159.
[8]
Tozer DJ, Jager HR, Danchaivijitr N, et al. Apparent diffusion coefficient histograms may predict low-grade glioma subtype. NMR Biomed, 2007, 20(1): 49-57.
[9]
Liu Q, Peng WJ, Zhou ZR. Oligodendroglial tumors: can relative apparent diffusion coefficient be used in prediction of tumor grade and subtype. Chin Computed Med Imaging, 2008,14(4):287-292.
[10]
Bulakbasi N, Kocaoglu M, Ors F, et al. Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors. AJNR Am J Neuroradiol, 2003, 24(2): 225-233.
[11]
Kono K, Inoue Y, Nakayama K, et a1. The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol, 2001, 22(6): 1081-1088.

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