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• Clinical Article •
Correlation between angiogenesis and multi-parameters of dynamic contrast enhancement MRI for assessments of benign and malignant breast lesions
LI Min  JIN Zhen  LI Gong-jie  ZHANG Lei  ZENG Ya-wei  LI Ke  CUI Yan  ZHANG Jian-zhong 

DOI:10.3969/j.issn.1674-8034.2010.01.010.


[Abstract] Objective: To explore the correlation between microvessel density (MVD), vascular endothelial growth factor (VEGF) and multi-parameters of dynamic contrast-enhanced (DCE) MRI, and the parameters’ value for assessments of benign/malignant breast lesions. The multi-parameters includes: the type of time-signal intensity curve (TIC), early-phase enhancement rate (EER), maximum linear slope rate (Slope), maximum enhancement rate (SImax), peak time (Tpeak), the number of tumor vessels on maximum intensity projection map (NTV).Materials and Methods: Fifty-two patients with breast lesions received preoperative DCE-MRI scans. All DCE parameters were recorded for correlation analysis. All patients were operated within 1 week after DCE-MRI. Histopathological and immunohistochemical exams were performed on the excisions to determine malignancy and the expression of marginal MVD, central MVD and VEGF. Correlations between DCE-MRI parameters and MVD, VEGF were analyzed.Results: The marginal MVD and VEGF demonstrated linear correlation with TIC, Tpeak and NTV. Strongest correlation was found between TIC and marginal MVD, as well as between Tpeak and VEGF. Central MVD has no significant correlation with all DCE parameters. Among the 52 patients, there were 22 malignant and 30 benign lesions. In comparison with benign lesions, the malignant lesions showed a washout TIC type III, higher EER, more NTV, and high expression of MVD and VEGF, but lower SImax and Tpeak (P<0.005). Slope has no significant difference between malignant and benign groups.Conclusion: Among the DCE-MRI parameters, TIC, Tpeak, and NTV demonstrated correlation with MVD and VEGF, those parameters may reflecting the different angiogenesis between malignant and benign breast lesions, and therefore are most meaningful for the diagnosis of breast lesions.
[Keywords] Breast diseases；Dynamic contrast-enhancement；Magnetic resonance imaging；Vascular endothelial growth factor

LI Min MRI Center, PLA 306th Hospital, Beijing 100101, China

JIN Zhen* MRI Center, PLA 306th Hospital, Beijing 100101, China

LI Gong-jie Department of Radiology, PLA 307th Hospital, Beijing 100071, China

ZHANG Lei MRI Center, PLA 306th Hospital, Beijing 100101, China

ZENG Ya-wei MRI Center, PLA 306th Hospital, Beijing 100101, China

LI Ke MRI Center, PLA 306th Hospital, Beijing 100101, China

CUI Yan Department of Surgery, PLA 306th Hospital, Beijing 100101, China

ZHANG Jian-zhong Department of Pathology, PLA 306th Hospital, Beijing 100101, China

*Correspondence to: Jin Z, E-mail: mdjinzhen@163.com

Conflicts of interest   None.

Received  2010-01-02
Accepted  2010-01-15
DOI: 10.3969/j.issn.1674-8034.2010.01.010
DOI:10.3969/j.issn.1674-8034.2010.01.010.

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