• Clinical Article •
Correlation between the severity of acute pancreatitis on MR imaging and liver function
DOI:10.3969/j.issn.1674-8034.2010.01.012.
| [Abstract] Objective: To investigate the correlation between the severity of acute pancreatitis (AP) on MR imaging and liver function.Materials and Methods: There were 64 patients with AP, all of whom had performed abdominal MR imaging. AP was categorized into types of edematous and necrotizing, and graded into mild (0-3 scores), moderate (4-6 scores) and severe (7-10 scores) according to the MR severity index (MRSI). The results of liver function test (ALT and AST) was noted and compared with the severity of AP on MRSI.Results: In the 64 patients with AP, 56 patients were edematous and 8 patients were necrotizing on MR imaging. The frequencies of ALT and AST elevated were both 100% in necrotizing AP, which were significantly larger than 55.4% (ALT) and 60.7% (AST) in edematous AP (P=0.014 and P=0.027, respectively). The frequencies of ALT and AST elevated were 48.8% and 53.5% in mild AP, 73.7% and 78.9% in moderate AP, and both 100% in severe AP, respectively. The frequency increasing of liver function abnormality tended to follow MRSI scores increasing. However, no significant difference for the frequencies can be seen among mild, moderate and severe AP.Conclusion: The necroses of AP on MR imaging may help to predict liver function abnormality in AP. However, MRSI could not be as index for predicting the abnormality of liver function in AP. |
| [Keywords] Pancreatitis, acute necrotizing；Magnetic resonance imaging；Severity of illness index；Liver failure |
TANG Wei Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
ZHANG Xiao-ming* Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
HUANG Xiao-hua Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
XIAO Bo Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
ZENG Nan-lin Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
ZHAI Zhao-hua Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
*Correspondence to: Zhang XM, E-mail: zhangxm@nsmc.edu.cn
Conflicts of interest None.
| Received 2010-01-06 |
| Accepted 2010-01-15 |
| DOI: 10.3969/j.issn.1674-8034.2010.01.012 |
| DOI:10.3969/j.issn.1674-8034.2010.01.012. |
[1]
Jaffray C, Yang J, Norman J. Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators. J Surg Res, 2000, 90(2): 95-101.
[2]
Isogai M, Yamaguchi A, Hori A, et al. Hepatic histopathological changes in biliary pancreatitis. Am J Gastroenterol, 1995, 90(3): 449-454.
[3]
Armbruster C, Kriwanek S. Multicentre audit of death from acute pancreatitis. Br J Surg, 1994, 81(6): 890-893.
[4]
Arvanitakis M, Koustiani G, Gantzarou A, et al. Staging of severity and prognosis of acute pancreatitis by computed tomography and magnetic resonance imaging a comparative study. Dig Liver Dis, 2007, 39(5): 473-482.
[5]
Kim YK, Ko SW, Kim CS, et al. Effectiveness of MR imaging for diagnosing the mild forms of acute pancreatitis: comparison with MDCT. J Magn Reson Imaging, 2006, 24(6): 1342-1349.
[6]
Balthazar EJ, Robinson DL, Megibow AJ, et al. Acute pancreatitis: value of CT in establishing prognosis. Radiology, 1990, 174(2): 331-336.
[7]
Vriens PW, van de Linde P, Slotema ET, et al.Computed tomography severity index is an early prognostic tool for acute pancreatitis. J Am Coll Surg, 2005, 201(4): 497-502.
[8]
Viremouneix L, Monneuse O, Gautier G, et al. Prospective evaluation of nonenhanced MR imaging in acute pancreatitis. J Magn Reson Imaging, 2007, 26(2): 331-338.
[9]
Stimac D, Miletic D, Radic M, et al. The role of nonenhanced magnetic resonance imaging in the early assessment of acute pancreatitis. Am J Gastroenterol, 2007, 102(5): 997-1004.
[10]
Dholakia K, Pitchumoni CS, Agarwal N. How often are liver function tests normal in acute biliary pancreatitis? J Clin Gastroenterol, 2004, 38(1): 81-83.
[11]
Sun ZQ, Mao YL. Liver function enzyme index and its clinical application. Chin J Lab Med, 2005, 28(6): 659-662.
[12]
Chen HM, Hwang TL, Chen MF. The effect of gabexate mesilate on pancreatic and hepatic m icrocirculation inacute pancreatitis in rats. J Surg Res, 1996, 66 (2): 147-153.
[13]
Cohen ME, Slezak L, Wells CK, et al. Prediction of bile duct stones and complications in gallstone pancreatitis using early laboratory trends. Am J Gastroenterol, 2001, 96(12): 3305-3311.
[14]
Taylor SL, Morgan DL, Denson KD, et al. A comparison of the Ranson, Glasgow, and APACHE II scoring systems to a multiple organ system score in predicting patient outcome in pancreatitis. Am J Surg, 2005, 189(2): 219-222.
[15]
Arvanitakis M, Delhaye M, De Maertelaere V, et al. Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology, 2004, 126(3): 715-723.
