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• Technical Article •
Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted and diffusion-tensor MR imaging
MU Liang  YANG Jian  YU bo-lang 

DOI:10.3969/j.issn.1674-8034.2010.01.015.


[Abstract] Hypoxic-ischemic encephalopathy (HIE) is the primary cause of neurological disorders during perinatal period. The pathophysiologic mechanism and patterns of injury in HIE are intricacy. There are different patterns in magnetic resonance imaging (MRI) as the results of the differences in brain maturity, severity and duration of insult. In this article, we review the principle of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI), and their advantage for detection of HIE. The changes of DWI and DTI parameters in neonatal HIE were retrospectively analyzed and summarized according to the previous literatures. It indicates that DWI and DTI are earlier and more sensitive than the conventional MRI in detecting the lesion of neonatal HIE. Moreover, the DWI parameter is associated with the variation in cellular and molecular level. The injury in neural microstructures, such as the axon and myelin, can be illustrated by DTI fiber tracking and performed quantitative analysis by different DTI parameters. Therefore, it is no doubt that these new approaches in MRI techniques can help diagnosis, affect prognosis, and facilitate earlier treatment to the neonatal HIE in clinic.
[Keywords] Hypoxic-ischemic encephalopathy, neonatal；Diffusion-weighted imaging；Diffusion-tensor imaging；Magnetic resonance imaging

MU Liang Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

YU bo-lang Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

*Correspondence to: Yang J, E-mail: cjr.yangjian@vip.163.com

Conflicts of interest   None.

Received  2010-01-03
Accepted  2010-01-15
DOI: 10.3969/j.issn.1674-8034.2010.01.015
DOI:10.3969/j.issn.1674-8034.2010.01.015.

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