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• Clinical Article •
Diffusion tensor imaging parameter maps of projection fibers from the brain in right-handed healthy young volunteers
LI Cui-ning  LIU Huai-jun  JIA Lin-yi  GENG Zuo-jun  CHI Chen  CUI Cai-xia  HUANG Bo-yuan 

DOI:10.3969/j.issn.1674-8034.2010.02.008.


[Abstract] Objective: To quantitatively analyze the diffusion tensor imaging parameter maps of the right-handed young human projection fibers, reveal the significance and correlation of three diffusion parameters: fractional anisotropy (FA), mean diffusivity (MD) and T2-weighted trace.Materials and Methods: Thirty right-handed healthy young volunteers (16 men, 14 women; mean age of 28.2 years) underwent diffusion tensor imaging and conventional MR imaging with a GE 3T MR system. The FA, MD and T2-weighed trace were determined at six-pair of parts of the projection fibers. The gender, lateral and regional differences of the parameters values were tested, the correlation between different parameters were analyzed.Results: (1) No significant differences were found in FA, MD and T2-weighted trace due to gender. (2) The FA value of projection fibers in the left pons was superior to that in the right (P=0.011), whereas the other five-pair regions of the fibers had no lateral differences. T2-weighted trace had lateral differences in the pons, peduncle, anterior limb of internal and centrum semiovale (P value was 0.000 to 0.017). (3) The order of FA values was peduncle > posterior limb of internal capsule > genu of internal capsule > anterior limb of internal capsule, pons > centrum semiovale. (4) In the projection fibers, T2-weighted trace had negative correlation with FA and MD (r=-0.169, P=0.024; r=-0.149, P=0.047).Conclusion: In showing the projection fibers, FA can give more details than the other two parameters. FA and MD are different parameters which reflect different aspect of the water molecule diffusion. T2-weighted trace map should be analyzed combining with FA, MD map and conventional MR imaging.
[Keywords] Brain；Projection fibers；Aanisotropy；Diffusion tensor imaging；T2-weighted trace

LI Cui-ning Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

LIU Huai-jun* Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

JIA Lin-yi Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

GENG Zuo-jun Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

CHI Chen Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

CUI Cai-xia Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

HUANG Bo-yuan Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

*Correspondence to: Liu HJ, E-mail: huaijunliu@yahoo.com.cn

Conflicts of interest   None.

Received  2010-01-11
Accepted  2010-02-15
DOI: 10.3969/j.issn.1674-8034.2010.02.008
DOI:10.3969/j.issn.1674-8034.2010.02.008.

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