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• Technical Article •
Comparison of three different post-processing techniques on the absolute quantitation of 1H MR spectroscopy
GUO Xiu-qin  XIAO Ye-yu  SHEN Zhi-wei  XU Zhi-feng  PANG Li  NING Li-bo  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2010.02.009.


[Abstract] Objective: To compare the accuracy of three different kinds of post-processing techniques: LCModel, Functool and SAGE software in the estimation of metabolite concentration.Materials and Methods: Fourteen health volunteers with an average age of 26.1 years old were selected for this study. All the 1H MR spectroscopy data were collected by STEAM sequence. The scan parameters were as followed: TE=30 ms, TR=3000 ms.Results: Except for NAA/Cr, the ratios of Cho/Cr and mI/Cr were significant different for the three post-processing technologies. Cho/Cr obtained from LCModel software was obviously deviated from the reference. NAA/Cr and mI/Cr analyzed by Functool software were also deviated from the reference. What’s more, the concentration translated from the peak areas through a known formula, Cho/Cr and mI/Cr were still deviated from the reference when we analyzed the spectrum by SAGE software.Conclusion: Compared with Functool and SAGE softwares, LCModel software shows an advantage at the quantitation because of simulating the base-line spectrum and handling the systematic error. However, LCModel software was still weak at the calculation of metabolite concentration.
[Keywords] Magnetic resonance spectroscopy；STEAM；LCModel；Functool；SAGE；Quantitation

GUO Xiu-qin Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

XIAO Ye-yu Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

SHEN Zhi-wei Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

XU Zhi-feng Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

PANG Li Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

NING Li-bo Engineering College of Shantou University, Shantou 515063, China

WU Ren-hua* Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: rhwu@stu.edu.cn

Conflicts of interest   None.

Received  2010-01-06
Accepted  2010-02-13
DOI: 10.3969/j.issn.1674-8034.2010.02.009
DOI:10.3969/j.issn.1674-8034.2010.02.009.

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