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• Original Article •
Perfusion-weighted imaging of rabbit models with hepatic VX2 tumor after three-dimensional conformal radiotherapy: compared with pathological changes
JIANG Xin-qing  CHEN Liang  WEI Xin-hua  WU Hong-zhen  LIU Zhen 

DOI:10.3969/j.issn.1674-8034.2010.02.011.


[Abstract] Objective: To analyze the perfusion parameters and related pathological changes of rabbit VX2 liver cancer after three-dimensional conformal radiotherapy (3DCRT) and discuss the availability of perfusion-weighted imaging (PWI) as a clinical diagnosis of liver tumors, postoperative monitoring and efficacy evaluation.Materials and Methods: Of 13 New Zealand rabbits were implanted in liver with VX2 tumor by tissue block, each rabbit was treated by single 3DCRT. All of them were performed PWI and enhanced scanning 10 days before and after the radiotherapy by using a 1.5T MR scanner with EPI-SE sequence and SENSE technology. Finally, image quality of 3 rabbits were not good enough, 13 were enrolled into statistic. Selecting the regions of interests (ROI) of lesions and surrounding normal liver tissue, perfusion values were measured and statistically analyzed. Maximal signal reduction slope (SRSmax) of the signal intensity versus time curves were created as quantitative index, specimens of vascular endothelial growth factor (VEGF) were examined and compared with the perfusion-weighted images.Results: After radiotherapy, the SRSmax value of central and surrounding of tumor were statistically decreased than that before radiotherapy (P<0.05), but there were no differences in normal liver parenchyma of tumor border; the SRSmax decreasing of different ROI was accordant to the range of the spoiled vascular endothelial growth factor (r=0.487, P=0.01).Conclusion: PWI can reflect the microcirculation and hemodynamic changes of rabbit models with hepatic VX2 tumors after 3DCRT. SRSmax can be used as an evaluating indicator for living tumor microvessels.
[Keywords] Carcinoma, hepatocellular；Magnetic resonance imaging, perfusion；Rabbits；Vascular endothelial growth factor

JIANG Xin-qing Department of Radiology, the First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China

CHEN Liang* Department of Radiology, the First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China

WEI Xin-hua Department of Radiology, the First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China

WU Hong-zhen Department of Radiology, the First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China

LIU Zhen Department of Radiology, the First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China

*Correspondence to: Chen L, E-mail: jarod416@126.com

Conflicts of interest   None.

Received  2010-01-02
Accepted  2010-03-02
DOI: 10.3969/j.issn.1674-8034.2010.02.011
DOI:10.3969/j.issn.1674-8034.2010.02.011.

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