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• Clinical Article •
Prostate cancer detection: comparison of T2-weighted imaging, diffusion-weighted imaging, proton magnetic resonance spectroscopy, and the combination of three techniques
LI Chun-mei  CHEN Min  LI Sa-ying  WANG Wen-chao  ZHAO Wei-feng  YANG Zheng-han  LIU Ming  ZHOU Cheng 

DOI:10.3969/j.issn.1674-8034.2010.04.004.


[Abstract] Objective: To evaluate T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and the combination of the three MR techniques in the diagnosis of prostate cancer, as correlation with histopathologic findings.Materials and Methods: MR imaging, including T2WI, DWI, and MRS, was performed at 1.5 T MR scanner with a body coil combined with a spine coil in 42 cases. Diagnosis was confirmed by histopathology through systematic transrectal prostate biopsy. All cases were evaluated by T2WI, DWI, MRS, and then by the three methods combined. The statistical indicators and the receiver operating characteristic (ROC) curve analysis of each method were compared to histopathological findings obtained by transrectal prostate biopsy.Results: Fifteen of 42 cases were confirmed to be cancerous, and 27 of 42 cases were noncancerous. All the 252 sextants were confirmed by biopsies, including 201 benign sextants and 51 malignant sextants. The sensitivity and the specificity for the detection of prostate cancer were 88.2% and 67.2% for T2WI, as the cutoff was 3; 82.4% and 81.6% for DWI, as the cutoff was 4; 84.3% and 98.0% for MRS, as the cutoff was 5; and 96.1% and 96.5% for the combined T2WI+DWI+MRS, as the cutoff was 4. In the ROC analysis, the correlative areas under the ROC curves (Az) were 0.848±0.030, 0.860±0.033, and 0.961±0.016 for T2WI, DWI, and MRS, respectively, and 0.978±0.009 for the combination of T2WI+DWI+MRS.Conclusion: Prostate cancer can be diagnosed effectively by T2WI, DWI and MRS separately. The diagnostic accuracy of prostate cancer is increased through a combination of the three techniques. Moreover, MRS demonstrated higher accuracy comparing with T2WI or DWI.
[Keywords] Prostate neoplasms；T2-weighted imaging；Diffusion-weighted imaging；Magnetic resonance spectroscopy

LI Chun-mei Department of Radiology, Beijing Hospital, Beijing 100730, China

CHEN Min* Department of Radiology, Beijing Hospital, Beijing 100730, China

LI Sa-ying Department of Radiology, Beijing Hospital, Beijing 100730, China

WANG Wen-chao Department of Radiology, Beijing Hospital, Beijing 100730, China

ZHAO Wei-feng Department of Radiology, Beijing Hospital, Beijing 100730, China

YANG Zheng-han Department of Radiology, Beijing Hospital, Beijing 100730, China

LIU Ming Department of Urology, Beijing Hospital, Beijing 100730, China

ZHOU Cheng Department of Radiology, Beijing Hospital, Beijing 100730, China

*Correspondence to: Chen M, E-mail: chenmin62@yahoo.com

Conflicts of interest   None.

Received  2010-06-15
Accepted  2010-07-05
DOI: 10.3969/j.issn.1674-8034.2010.04.004
DOI:10.3969/j.issn.1674-8034.2010.04.004.

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