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• Clinical Article •
Value of apparent diffusion coefficient to differentiate prostate cancer in central gland from benign prostate hyperplasia
WANG Cui-yan  ZHU Xiang-yu  WANG Jing  ZHANG Xin-juan  QIU Xiu-ling  WEI Yu-long  WANG Guang-bin 

DOI:10.3969/j.issn.1674-8034.2010.04.006.


[Abstract] Objective: To evaluate the ability of apparent diffusion coefficient (ADC) to differentiate prostate cancer (PCa) of the central gland (CG) from benign prostate hyperplasia (BPH).Materials and Methods: Twenty-three PCa cases of CG and 23 BPH cases were divided into PCa group and BPH group, who had been performed MR diffusion weighted imaging (DWI) and pathologically confirmed. DWI sequence was performed with three b values (300, 500, and 800 s/mm2), and ADC map was automatically generated. Signal-to-noise ratio (SNR) of DW images and the ADC values of the same lesion in each group were measured under different b values, and paired t test was used to verify the difference of SNR and the ADC values of the same lesions with different b values. Independent sample t test was used to verify the difference of the ADC values between PCa and BPH with the same b value. ROC analysis was used and the area under the curve (Az), sensitivity and specificity were calculated.Results: PCa lesions of CG were presented with hyperintensity on DWI and hypointensity on ADC map. The difference of SNR and the ADC values of the same lesions with different b values were of statistic significance (P<0.001); ADC values between PCa and BPH with the same b value were of statistic significant difference (P<0.001). When b=300, 500, 800 s/mm2, Az of the ROC was 0.89, 0.91, 0.94, respectively. The sensitivity and specificity of ADC value to identify PCa from BPH both reached 87% when b=800 s/mm2 with the cutoff of 1.305.Conclusion: ADC value of PCa lesions of CG decreases commonly, with significant differences with that of BPH, which makes ADC value significant to differentiate PCa of CG with BPH.
[Keywords] Magnetic resonance imaging；Apparent diffusion coefficient；Prostate neoplasms；Central gland；Benign prostate hyperplasia

WANG Cui-yan Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

ZHU Xiang-yu Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

WANG Jing Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

ZHANG Xin-juan Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

QIU Xiu-ling Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

WEI Yu-long Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

WANG Guang-bin* Department of MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China

*Correspondence to: Wang GB, E-mail: cjr.wangguangbin@vip.163.com

Conflicts of interest   None.

Received  2010-06-15
Accepted  2010-07-05
DOI: 10.3969/j.issn.1674-8034.2010.04.006
DOI:10.3969/j.issn.1674-8034.2010.04.006.

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