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• Clinical Article •
Diffusion-weighted imaging in the detection and differentiation of prostate cancer
LIANG Yu-ting  JIN Er-hu  ZHANG Yi  DENG Li-gang  FU Jing-yuan 

DOI:10.3969/j.issn.1674-8034.2010.04.007.


[Abstract] Objective: To determine the value of diffusion-weighted imaging (DWI) for the detection and differentiation of the prostate cancer.Materials and Methods: 87 patients were included in the study. 41 cases were confirmed pathologically to be prostate cancer and 46 to be benign hyperplasia (BPH). Axial T2WI, DWI and DCE-MRI were performed under a 3.0 T MRI scanner. An echo-planar imaging DWI technique with b=0 and b=1000 s/mm2 were used. In cancer group, the ADC values were measured in malignant and benign tissues using regions of interest (ROI). In BPH group, the ADC values were measured in both transitional zone (TZ) and peripheral zone (PZ).Results: Among 41 cancer patients, tumors located in PZ in 28 patients, in TZ in 5 patients, tumors involved both PZ and TZ in 8 patients. The size of the smallest tumor which can be measured in ADC map was 0.8 cm. The mean ADC values of the malignant and benign tissues in the cancer group were (0.97 ± 0.25)×10-3 mm2/s and(1.34 ± 0.16)×10-3 mm2/s. The mean ADC values of PZ and TZ in the BPH group were (1.37 ± 0.24)×10-3 mm2/s and(1.43 ± 0.31)×10-3 mm2/s, respectively. The mean ADC value of the malignant tissue was significantly lower than the benign tissues in cancer group and in BPH group as well (P<0.001), while no significant difference was observed between the benign tissue in cancer group and those in BPH group.Conclusion: DWI and ADC value could help to detect and differentiate prostate cancer with hyperplasia. T2WI combined with DWI may increase the detection of prostate cancer, especially in the apex and transitional zone.
[Keywords] Prostate neoplasms；Benign prostate hyperplasia；Diffusion-weighted imaging；Magnetic resonance imaging

LIANG Yu-ting Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

ZHANG Yi Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

DENG Li-gang Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

FU Jing-yuan Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net

Conflicts of interest   None.

Received  2010-06-15
Accepted  2010-07-05
DOI: 10.3969/j.issn.1674-8034.2010.04.007
DOI:10.3969/j.issn.1674-8034.2010.04.007.

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