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• Clinical Article •
Tumor measurement methods in adult glioblastoma: comparison of linear and volumetric criteria
WANG Mei-yun  CHENG Jing-liang  SHI Da-peng 

DOI:10.3969/j.issn.1674-8034.2010.04.008.


[Abstract] Objective: The changes in tumor size before and after treatment should be measured using volumetric or linear methods is not certain. We compared and analyzed the value of linear and volumetric measurements in evaluating tumor response in glioblastoma (GBM).Materials and Methods: Linear and volumetric measurements for tumor were performed on 112 MRI studies from 30 adult patients with GBM on post-contrast T1WI. Fifty-six pairs of MRI scans were analyzed for relative changes. Radiographic responses were determined based on changes in two methods respectively.Results: The correlation of tumor size measured by linear compared to volumetric method was good (P<0.001). Lower correlation was present when comparing percentage changes between pairs (n=56) (P<0.001). When these percentage changes were categorized into traditional tumor response criteria (complete response/partial response/stable disease/progression), 45 of 56 pairs were accordant and there was no significant difference between the two methods. A review of 11 discordant pairs suggested that the volumetric method was more accurate than linear method in 8 cases in assessing tumor response, while linear was better than volumetric method in 3 ones.Conclusion: Volumetric approach for measuring tumor response is more accurate than linear method in some special tumor lesions.
[Keywords] Glioblastoma；Photogrammetry；Magnetic resonance imaging；Comparative study

WANG Mei-yun Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China

CHENG Jing-liang MRI Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

SHI Da-peng* Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China

*Correspondence to: Shi DP, E-mail: cjr.shidapeng@vip.163.com

Conflicts of interest   None.

Received  2010-03-01
Accepted  2010-04-13
DOI: 10.3969/j.issn.1674-8034.2010.04.008
DOI:10.3969/j.issn.1674-8034.2010.04.008.

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