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• Clinical Article •
MR spectroscopy for evaluation of cognitive impairment in AIDS patients
WANG Ling  SHI Da-peng  HAN Xiong  ZHAO Qing-xia  YAN Bin  LI Hong-jun 

DOI:10.3969/j.issn.1674-8034.2010.05.007.


[Abstract] Objective: To assess the value of MR spectroscopy in the diagnosis of cognitive impairment in AIDS patients.Materials and Methods: 3.0 T MR was used to measured NAA, Cho, MI and Cr in the frontal white matter, basal ganglia and parietal cortex of 21 AIDS patients with dementia complex (ADC), 19 neuroasymptomatic AIDS patients (NAS) and 20 seronegative controls (SN), respectively; and then compared the difference of metabolic rate between AIDS patients and SN controls.Results: NAA/Cr (1.2502) was significantly decreased and Cho/Cr (1.2028) was increased in the frontal white matter in ADC group, while NAA/Cr (1.5334) was reduced in NAS group compared with that in SN group, NAA/Cr in the basal ganglia was decreased in both ADC and NAS groups (1.2625 and 1.5278, respectively), Cho/Cr (1.1631) was obviously increased in ADC group. Although NAA/Cr, Cho/Cr and MI/Cr in the parietal cortex had some degree of change in both ADC and NAS groups compared with SN group, but the difference has not statistically significant.Conclusion: The brain metabolite changes of AIDS patients are correlated with cognitive impairment. MR spectroscopy can be used as a valuable method to assess cognitive impairment in AIDS patients.
[Keywords] AIDS；Cerebral metabolites；Cognitive impairment；Magnetic resonance spectroscopy

WANG Ling Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China

SHI Da-peng Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China

HAN Xiong Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China

ZHAO Qing-xia Henan Province Infectious Disease Hospital, Zhengzhou 450061, China

YAN Bin PLA Information Engineering University, Zhengzhou 450001, China

LI Hong-jun Department of Diagnostic Radiology, Affiliated Beijing You'an Hospital, Capital Medical University, Beijing 100069, China

*Correspondence to: Shi DP, E-mail: shihn1956@126.com

Conflicts of interest   None.

Received  2010-07-13
Accepted  2010-08-25
DOI: 10.3969/j.issn.1674-8034.2010.05.007
DOI:10.3969/j.issn.1674-8034.2010.05.007.

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