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• Clinical Article •
Imaging appearance of toxoplasma encephalopathy in AIDS patients
HUANG Hua  DENG Ying-ying  LU Pu-xuan  MA Wei  ZHU Wen-ke  YANG Gen-dong  YE Ru-xin 

DOI:10.3969/j.issn.1674-8034.2010.05.008.


[Abstract] Objective: To characterize the cranial imaging findings of toxoplasma encephalopathy in AIDS patients.Materials and Methods: A retrospective review of 10 human AIDS patients with toxoplasma encephalopathy was performed. Head computed tomography (CT) and magnetic resonance imaging (MRI) were reviewed.Results: There were 30 lesions found in 10 patients, the number of lesions for each patient ranged from 2 to 7, there were 20 nodular or oval lesions among the 30 lesions. Before contrast injection, all the lesions were low density on CT; after intravenous contrast injection, there were 7 lesions showed ring enhancement. For the MRI, all lesions were predominantly hypointense on T1-weighted images, all the lesions were hyperintense on T2-weighted images. Post-contrast imaging revealed ring enhancement in 8 lesions, including 2 target enhancement. Patients with CD4+ T lymphocyte count above 50 cell/μl compared with CD4+ T lymphocyte count less than 50 cell/μl was more likely with ring or nodular enhancement (Chi-square test, P=0.009).Conclusion: Toxoplasma encephalopathy showed multiple lesions, many of the lesions involved the cerebral hemispheres, basal ganglia and thalamus, the lesions form were predominantly nodular or oval, patients with relatively higher CD4+ T lymphocyte count was of more ring enhancement after injection of contrast agent.
[Keywords] Immunodeficiency virus, human；AIDS；Toxoplasmosis, cerebral；Computed tomography；Magnetic resonance imaging

HUANG Hua Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

DENG Ying-ying Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

LU Pu-xuan* Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

MA Wei Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

ZHU Wen-ke Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

YANG Gen-dong Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

YE Ru-xin Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518020, China

*Correspondence to: Lu PX, E-mail: lupuxuan@126.com

Conflicts of interest   None.

Received  2010-07-13
Accepted  2010-08-25
DOI: 10.3969/j.issn.1674-8034.2010.05.008
DOI:10.3969/j.issn.1674-8034.2010.05.008.

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