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• Review •
Current status of magnetization transfer imaging in psychiatric disorders
ZHANG Ti-jiang  GONG Qi-yong 

DOI:10.3969/j.issn.1674-8034.2010.06.015.


[Abstract] For many central nervous system diseases, MRI has been proved to be a sensitive tool for detecting abnormalities, understanding site and extent of lesions. Despite such a high sensitivity, conventional MRI does not provide an accurate assessment for subtle or early neuropathological changes in some disorders. Magnetization transfer imaging (MTI) is a relative new, more sensitive MRI technique to detect subtle pathological changes of macromolecular structure. MTI can selectively decrease macromolecular tissue signal through applying off-resonance saturating pulses, thus improving image contrast and acquiring more tissue structural information. Many studies have suggested that MTI can detect brain abnormalities of normal-appearing white and gray matter on conventional MRI, such as multiple sclerosis. Recently, there is growing evidence that MTI can provide new complementary information for better understanding pathophysiological mechanism of psychiatric disease. In this review, we summarized clinical application and advancement of MTI in psychiatric disorders.
[Keywords] Magnetization transfer imaging；Psychiatric disorders；Magnetic resonance imaging

ZHANG Ti-jiang Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

GONG Qi-yong* Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China

*Correspondence to: Gong QY, E-mail: qygong05@126.com

Conflicts of interest   None.

Received  2010-04-21
Accepted  2010-08-05
DOI: 10.3969/j.issn.1674-8034.2010.06.015
DOI:10.3969/j.issn.1674-8034.2010.06.015.

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