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• Clinical Article •
Continuous arterial spin labeling MR perfusion imaging in diagnosis of hypoxic ischemic encephalopathy in full-term neonates: Preliminary study
JI Xu  FAN Guo-guang 

DOI:10.3969/j.issn.1674-8034.2011.01.006.


[Abstract] Objective: To investigate continuous arterial spin labeling (CASL) MR perfusion imaging in the quantitatively evaluation of early hemodynamic change in patients suffered from hypoxic ischemic encephalopathy (HIE).Materials and Methods: Twelve cases of full-term neonates suffered from HIE and 12 normal controls in 8-24 hours, 48 hours, and 7-12 days were recruited for MR T1 weighted, T2 weighted, diffusion weighted imaging, and CASL examination . Cerebral blood flow (CBF) colour maps were obtained using Functool II package, and CBF values of bilateral patietal cortex, corona radiata, and basal ganglia were calculated.Results: CBF of patietal cortex was lower than that of basal ganglia (P<0.01), and CBF of white matter was lower than that of cortex (P<0.01) in normal full-term neonates. CBF values in patients were significant decreased in each region of interest at 8-24 hours postnatal timepoint when compared with normal controls (P<0.05); However, no significant difference of CBF values in white matter, and significant difference of CBF values in both cortex and basal ganglia (P<0.05) were present 48 hours after hypoxic insult. There was no significant difference of CBF values in each region of interest 7-12 days after hypoxic insult when patients and normal controls were compared. Forty-eight hours after birth, the experimental group parietal cortex and basal ganglia (P<0.05) appeared congestive phenomena.Conclusion: CASL MR perfusion imaging plays an important role in the early diagnosis of HIE.
[Keywords] Continuous arterial spin labeling；Full term neonate；Hypoxic ischemic encephalopathy；Cerebral blood flow

JI Xu Department of Radiology, Beijing Changping District Hospital, Beijing 102200, China

FAN Guo-guang* Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China

*Correspondence to: Fan GG, E-mail: fanguog@vip.sina.com

Conflicts of interest   None.

Received  2010-03-24
Accepted  2010-07-08
DOI: 10.3969/j.issn.1674-8034.2011.01.006
DOI:10.3969/j.issn.1674-8034.2011.01.006.

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