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• Clinical Article •
MRI diagnosis of hypothalamic hamartomas in children
YIN CHUN-hong  LI Yu-hua 

DOI:10.3969/j.issn.1674-8034.2011.01.008.


[Abstract] Objective: To sum up the typical or atypical MR imaging features of hypothalamic hamartoma and improve the diagnostic level of this disease.Materials and Methods: Eighteen cases of hypothalamic hamartomas were conformed by pathology, 12 males and 6 females, aged 1-15 years, mean 5.6±3.8 years. The clinical and MR imaging findings were retrospective analyzed. The clinic symptoms included precocious puberty (n=14) and gelastic epilepsy (n=7). All patients were examined with sagittal T1 and T2 weighted imaging, coronal T1 weighted imaging, sagittal and coronal T1 weighted imaging enhancement.Results: Typical performance of 8 cases were round or oval mass located or between pituitary stalk and the mammillary body, 8 cases showed iso-intensity on T1 weighted imaging, similar with grey matter and slight hyper-intensity on T2 weighted imaging, On contrast MR scan, there was no enhancement in all cases. In 10 atypical cases, 3 cases were with atypical location but typical signal (1 case was behind the saddle department, 1 case grew across the optic chiasm, 1 case was above the mammillary body); 7 cases were with typical location but atypical signal, they showed hypo-intensity or mixed intensity on T1 weighted imaging and hyper-intensity or mixed intensity on T2 weighted imaging.Conclusion It is not difficult to diagnose the hypothalamic hamartoma with typical location and MRI signal characteristics, when MRI signal or the location of lesions is not typical, combined with its clinical features that precocious puberty or gelastic epilepsy, a correct diagnosis may be achieved.
[Keywords] Hypothalamus；Hamartoma；Child；Magnetic resonance imaging

YIN CHUN-hong Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

LI Yu-hua Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

*Correspondence to: Li YH, E-mail: liyuhua10@sina.com

Conflicts of interest   None.

Received  2010-10-12
Accepted  2010-12-06
DOI: 10.3969/j.issn.1674-8034.2011.01.008
DOI:10.3969/j.issn.1674-8034.2011.01.008.

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