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• Clinical Article •
MRI diagnosis of fetal corpus callosum agenesis
DONG Su-zhen  ZHU Ming  ZHONG Yu-min  ZHANG Hong  PAN Hui-hong 

DOI:10.3969/j.issn.1674-8034.2011.01.009.


[Abstract] Objective: To explore the diagnostic value of MRI on fetal agenesis of corpus callosum (ACC).Materials and Methods: Thirty-nine pregnant women, aged from 19 to 35 years (average 29 years) and with gestation from 22-39 weeks (average 29 weeks) were studied with a 1.5 T superconductive MR unit within 24 to 48 hours after ultrasound examination. The imaging protocol included fast-imaging employing steady-state acquisition (FIESTA), single-shot fast spin echo (SSFSE), T1-weighted fast inversion recovery motion insensitive (FIRM) and diffusion-weighted imaging (DWI) sequences in the axial, frontal, and sagittal planes relative to the fetal brain, thorax, abdomen, especially brain. Prenatal US and MR imaging findings were compared with postnatal brain MRI diagnosis (20 fetuses) or postmortem examination (19 fetuses).Results: In 39 cases of ACC, 32 cases were complete agenesis and 7 were partial agenesis; 31 cases were simple ACC, 8 cases were with other malformations. Follow-up results were consistent with prenatal MRI diagnosis, prenatal US missed or misdiagnosed 19 cases of ACC or combined deformity.Conclusion Fetal MRI is currently the best means of diagnosing ACC. It can directly show the existence of the corpus callosum, and better show the combined brain malformation of ACC.
[Keywords] Fetus；Corpus callosum；Agenesis；Magnetic resonance imaging, prenatal

DONG Su-zhen Center of Imaging Diagnosis, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

ZHU Ming Center of Imaging Diagnosis, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

ZHONG Yu-min Center of Imaging Diagnosis, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

ZHANG Hong Center of Imaging Diagnosis, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

PAN Hui-hong Center of Imaging Diagnosis, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

*Correspondence to: Zhu M, E-mail: zhuming58@vip.sina.com

Conflicts of interest   None.

Received  2010-10-12
Accepted  2010-12-06
DOI: 10.3969/j.issn.1674-8034.2011.01.009
DOI:10.3969/j.issn.1674-8034.2011.01.009.

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