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• Clinical Article •
Correlation of microarchitecture and apparent diffusion coefficient value in astrocytoma
LIU Ying  ZENG Fei-yan  WANG Chang-xin  XU Yun-jun 

DOI:10.3969/j.issn.1674-8034.2011.01.012.


[Abstract] Objective: To analyze the difference of ADC in astrocytomas with different grade and the relationship between microarchitecture and ADC value using DWI at 3T.Materials and Methods: Seventeen patients with astrocytoma (including 5 I/II grade astrocytomas, 5 III grade astrocytomas and 8 IV grade astrocytomas) were examined. ADC of each case was obtained. Statistical analysis were performed using SPSS 11.0 package. One-Way ANOVA was used to analyze the difference of ADCs in different grade astrocytomas. Pearson correlations were calculated between ADC value and microarchitecture.Results: ADC tended to reduce from low- to high-grade astrocytomas and the differences between I/II grade and III or IV grade astrocytoma were significant. Significant correlations were revealed between ADC and MVD (r=-0.516, P=0.013) and ADC and cell density (r=-0.618, P=0.025).Conclusion: ADCs are different between low- and high-grade astrocytoma and can represent the microarchitecture in astrocytoma. DWI is helpful in preoperative grading of astrocytomas.
[Keywords] Astrocytoma；Apparent diffusion coefficient；Cell density；Microvessel density；Magnetic resonance imaging

LIU Ying* Department of MRI, Anhui Provincial Hospital, Hefei 230001, China

ZENG Fei-yan Department of MRI, Anhui Provincial Hospital, Hefei 230001, China

WANG Chang-xin Department of MRI, Anhui Provincial Hospital, Hefei 230001, China

XU Yun-jun Department of MRI, Anhui Provincial Hospital, Hefei 230001, China

*Correspondence to: Liu Y, E-mail: felice828@126.com

Conflicts of interest   None.

Received  2010-05-25
Accepted  2010-10-14
DOI: 10.3969/j.issn.1674-8034.2011.01.012
DOI:10.3969/j.issn.1674-8034.2011.01.012.

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