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• Clinical Article •
Elevated Lip signals on 1H-MR spectroscopy in differential diagnosis of intracranial lesions
PENG Juan  LUO Tian-you  LV Fa-jin  OUYANG Yu  FANG Wei-dong  WU Jing-quan 

DOI:10.3969/j.issn.1674-8034.2011.01.013.


[Abstract] Objective: To investigate the clinical value of elevated Lip signals on proton MR spectroscopy (1H-MRS) in the differential diagnosis of intracranial lesions.Materials and Methods: 125 patients with intracranial lesions were examined by conventional MR imaging and multivoxel 2D 1H-MRS before treatments or operations, including meningiomas (n=20), low-grade gliomas (n=19), high-grade gliomas (n=15), metastases (n=21 ), lymphomas (n=4), germinomas (n=3), teratomas (n=2), intraaxial tuberculomas (n=26 ), and brain abscesses (n=15). 1H-MRS was performed using PRESS sequence (TR 1000 ms, TE 144 ms). Concentrations of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) in the lesions were expressed as metabolite ratios. The ratios of Cho/Cr, Cho/NAA and positive ratio of Lip from the solid part of the lesions were calculated and analyzed.Results: There was significant difference on the positive ratios of lipid among the lesions (P<0.01). The positive ratios of lipid in lymphomas, germinomas, and teratomas were the highest and those of the low-grade gliomas and meningiomas were the lowest. Significant difference was also found on the ratios of Cho/Cr and Cho/NAA among the benign lesions, low-grade malignancy and high-grade malignancy (Cho/Cr were 1.92±0.75, 2.30±0.86, and 3.88±2.08 respectively, P<0.01; Cho/NAA were 1.80±0.92, 2.21±0.14, and 3.75±2.02 respectively, P<0.05). The ratios of Cho/Cr and Cho/NAA of high-grade malignancy were the highest and those of benign lesions were the lowest. There was no significant difference on the ratios of Cho/Cr and Cho/NAA between the benign lesions and low-grade malignancy.Conclusion: Elevated Lip signals reveal different pathological characteristics. Lip combined with Cho/Cr, Cho/NAA and conventional MR imaging plays an important role in the differential diagnosis of intracranial lesions.
[Keywords] Brain neoplasms；Intraaxial tuberculoma；Brain abscess；Magnetic resonance spectroscopy

PENG Juan Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

LUO Tian-you* Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

LV Fa-jin Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

OUYANG Yu Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

FANG Wei-dong Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

WU Jing-quan Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Luo TY, E-mail: ltychy@sina.com

Conflicts of interest   None.

Received  2010-07-19
Accepted  2010-10-14
DOI: 10.3969/j.issn.1674-8034.2011.01.013
DOI:10.3969/j.issn.1674-8034.2011.01.013.

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