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• Clinical Article •
Dynamic susceptibility contrast perfusion weighted MR imaging in grading of meningioma
WANG Fei-fei  CHENG Jing-liang  ZHAO Yi-lei  ZHANG Yong  YAN Chen-yu  BAI Jie  ZHANG Hui-xia  CUI Xiao-lin 

DOI:10.3969/j.issn.1674-8034.2011.01.014.


[Abstract] Objective: To investigate the feature and clinic value of dynamic susceptibility contrast perfusion weighted MR imaging (DSC-PWI) in different grades of meningioma.Materials and Methods: Total of 92 patients with meningiomas confirmed by operation and pathology underwent conventional MRI and DSC-PWI before resection using a 3.0 T MR unit. The perfusion color images and time-signal intensity curves (TIC) were analyzed. Maximal relative cerebral blood volume (rCBV) of the same ROI within both tumor parenchyma and peritumoral edema were calculated and the data were analyzed with unpaired Student’s t-test analysis. Grading and classifying of meningiomas were according to 2007 WHO classification and grading of tumors.Results: Seventy-eight patients suffered from benign meningiomas and 14 patients with malignat meningiomas. On the rCBV images, the perfusion in parenchyma of benign and malignant meningiomas increased, the perfusion of the peritumoral edema decreased in benign meningioma, and increased in malignant meningioma. The mean maximal rCBV values within the tumor parenchyma of the benign and malignant meningioma were 9.880±3.682 and 11.651±1.597 respectively (t=1.764, P=0.081). The mean maximal rCBV values within the peritumoral edema were 1.003±0.506 and 2.848±1.182 respectively (t=9.803, P=0.000). When the TIC were compared after the first pass, the decrease extent of signal intensity within the tumor parenchyma of all meningiomas were larger than the contralateral white mater, the decrease extent of signal intensity within the peritumoral region of benign meningiomas were less than or equal to the contralateral white mater, but in malignant meningiomas show that it is larger than the contralateral white mater.Conclusion: DSC-PWI can provide useful information in grading and subtyping of meningiomas.
[Keywords] Meningioma；Magnetic resonance imaging；Perfusion weighted imaging；Blood volume

WANG Fei-fei MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

CHENG Jing-liang MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

ZHAO Yi-lei MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

ZHANG Yong MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

YAN Chen-yu MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

BAI Jie MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

ZHANG Hui-xia MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

CUI Xiao-lin MRI Room of Radiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

*Correspondence to: Cheng JL, E-mail: cjr.chjl@vip.163.com

Conflicts of interest   None.

Received  2010-04-03
Accepted  2010-07-12
DOI: 10.3969/j.issn.1674-8034.2011.01.014
DOI:10.3969/j.issn.1674-8034.2011.01.014.

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