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• Clinical Article •
Role of diffusion-weighted MRI in detecting active sacroiliitis of ankylosing spondylitis
LI Jun  XU Jian-rong  CHEN Zeng-ai  LU Qing  GU Yue-ying 

DOI:10.3969/j.issn.1674-8034.2011.02.003.


[Abstract] Objective: To evaluate the value of diffusion-weighted imaging in detecting active sacroiliitis in patients with ankylosing spondylitis (AS).Materials and Methods: Based on the modified NEW YORK criteria for AS, 78 patients with chronic low back pain were diagnosed AS. They were divided into two groups as active group (n=34) and chronic group (n=44) by rheumatologist according to BASDAI and laboratory parameters. Twenty-five healthy adults were as control group. FSE-T1WI, FSE-T2WI, FS-FSE-T2WI, and DWI (SS-EPI) (b values: 0, 300 s/mm2) images were obtained in oblique conronal planar. Apparent diffusion coefficient (ADC) values of all sacroiliac joints (SIJs) were measured on ADC maps. ADC values of normal sacral were also measured. rADC(ADC of SIJ/ADC of sacral) was calculated. Mean (ADC) values and mean rADC values were compared between groups.Results: Mean ADC value of SIJs in active group (0.821×10-3 mm2/s) was significantly higher than that of control group (0.589×10-3 mm2/s) and chronic group (0.622×10-3 mm2/s). Mean ADC value of sacral in control group (0.635×10-3 mm2/s) was higher than that of active group (0.486×10-3 mm2/s) and chronic group (0.423×10-3 mm2/s). Multiple comparisons shows that differences of mean ADC value of sacral between groups were significant (P<0.05). rADC value of control group (0.959) was close to 1 and significantly lower than that of chronic group (1.558) and active group (1.752).Conclusion DWI is a sensitive, fast sequence. It is a good alternative for imaging sacroiliac joints. DWI also offers quantitive analysis of the lesions. It shows high value in detecting active sacroiliitis in patients with AS.
[Keywords] Diffusion weighted imaging；Active sacroiliitis；Ankylosing spondylitis；Chronic low back pain；Apparent diffusion coefficient

LI Jun Department of Radiology, Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China

XU Jian-rong* Department of Radiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

CHEN Zeng-ai Department of Radiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

LU Qing Department of Radiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

GU Yue-ying Department of Rheumatology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

*Correspondence to: Xu JR, E-mail: xujianr@hotmail.com

Conflicts of interest   None.

Received  2010-12-20
Accepted  2011-02-06
DOI: 10.3969/j.issn.1674-8034.2011.02.003
DOI:10.3969/j.issn.1674-8034.2011.02.003.

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