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• Clinical Article •
Differential diagnosis between cerebral lymphoma and gliomas multiblastoma by using of apparent diffusion coefficient
ZHANG De-hui  WANG Li-jun  WEI Qiang  SONG Qing-wei  MIAO Yan-wei 

DOI:10.3969/j.issn.1674-8034.2011.03.008.


[Abstract] Objective: To investigate diffusion-weighted MR images (DWI) features of primary intracerebral lymphoma and gliomas multiblastoma (GMB), and to further assess the differentiation between them by using apparent diffusion coefficient (ADC) value.Materials and Methods: Twelve patients with pathologically proved primary intra-cerebral lymphoma and 15 with GMB underwent MR examination, including DWI. The ADC values and ratio of ADC values (rADC) in solid parenchyma in all tumors were measured and compared between groups by two neuroradiologists.Results: Lymphoma showed slight-high or high intensity signal in DWI, and GMB were iso- or low intensity signal. Compared to normal appearing white matter, ADC values of lymphoma were significantly decreased [(0.593±0.176)×10-3 mm2/s, (0.773±0.057)×10-3 mm2/s, P=0.006], whereas those of GMB became obviously increased [(0.975±0.118)×10-3 mm2/s, (0.768±0.077)×10-3 mm2/s, P<0.001]. ADC values and rADC values were significantly different between lymphoma and GMB. Cutoff values to differentiate them were 0.805×10-3 mm2/s for ADC and 1.08 for rADC respectively.Conclusion: As a complementary method to conventional MR sequences, measurement of ADC value in DWI is helpful in the differentiated diagnosis on cerebral lymphoma and GMB.
[Keywords] Brain neoplasm；Lymphoma；Gliomas multiblastoma；Magnetic resonance imaging；Diffusion-weighted imaging

ZHANG De-hui Second Hospital of Panjin, Panjin 124000, China

WANG Li-jun Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

WEI Qiang Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

SONG Qing-wei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

MIAO Yan-wei* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Correspondence to: Miao YW, E-mail: ywmiao716@yahoo.com.cn

Conflicts of interest   None.

Received  2010-12-20
Accepted  2011-02-06
DOI: 10.3969/j.issn.1674-8034.2011.03.008
DOI:10.3969/j.issn.1674-8034.2011.03.008.

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