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Progress of the research on the role of key node of precuneus/posterior cingulated cortex in default brain functional network
SHAO Hui-li  DU Xiao-xia 

DOI:10.3969/j.issn.1674-8034.2011.03.011.


[Abstract] Previous studies have revealed that several regions of the brain constitute the default brain functional network. Many different tasks show that the precuneus/posterior cingulated cortex has a high degree interaction with other nodes than rest of the network. Evidence from the functional connectivity studies suggests that the precuneus/posterior cingulated cortex plays an important role in the default brain functional network. Analysis of the default brain functional network in different tasks shows that the brain functional network is scale-free with the properties of small world. From this point, the precuneus/posterior cingulated cortex maybe one of the key-node of the default brain function network.
[Keywords] Resting-state；Default mode network；Functional connectivity；Precuneus/posterior cingulated cortex

SHAO Hui-li* School of Fundmental studies, Shanghai university of engineering and Science, Shanghai, 201620, China

DU Xiao-xia Shanghai Key Laboratory of fMRI, East China Normal University, 200241, China

*Correspondence to: Shao HL, E-mail: huilishao@sues.edu.cn

Conflicts of interest   None.

Received  2010-06-22
Accepted  2011-01-07
DOI: 10.3969/j.issn.1674-8034.2011.03.011
DOI:10.3969/j.issn.1674-8034.2011.03.011.

[1]
Shulman GL, Fiez JA, Corbetta M, et al. Common blood flow changes across visual tasks: n. Decrease in cerebral cortex. J Cogn Neurosci, 1997, 9(5):648-663.
[2]
Mazoyer B, Zago L, Mellet E, et al. Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull, 2001, 54(3):287-298.
[3]
Raichle ME, MacLeod AM, Snyder AZ, et al. A default mode of brain function. Proc Natl Acad Sci U S A, 2001, 98(2):676-682.
[4]
Wirth M, Jann K, Dierks T, et al. Semantic memory involvement in the default mode network: A functional neuroimaging study using independent component analysis. Neuroimage, 2010, 54(4):3057-3066.
[5]
Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci, 2008, 1124:1-38.
[6]
Eguiluz VM, Chialvo DR, Cecchi GA, et al. Scale-free brain functional networks. Phys Rev Lett, 2005, 94(1):018102.
[7]
靳静,董峰,唐一源.探测静息状态大脑活动的关键区域.自然科学进展, 2007, 17(5):678-682.
[8]
Fransson P, Marrelec G. The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis. Neuroimage, 2008, 42(3):1178-1184.
[9]
Gusnard DA, Akbudak E, Shulman GL, et al. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A, 2001, 98(7):4259-4264.
[10]
Gusnard DA, Raichle ME, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci, 2001, 2(10):685-694.
[11]
Cabeza R, Nyberg L. Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci, 2000, 12(1):1-47.
[12]
Li ZH, Sun XW, Wang ZX, et al. Behavioral and functional MRI study of attention shift in human verbal working memory. Neuroimage, 2004, 21(1):181-191.
[13]
Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex, 1992, 2(6):435-443.
[14]
Bluhm RL, Miller J, Lanius RA, et al. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull, 2007, 33(4):1004-1012.
[15]
Kennedy DP, Courchesne E. The intrinsic functional organization of the brain is altered in autism. Neuroimage, 2008, 39(4):1877-1885.
[16]
Castellanos FX, Margulies DS, Kelly C, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry, 2008, 63(3):332-337.
[17]
Bai F, Zhang Z, Yu H, et al. Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study. Neurosci Lett, 2008, 438(1):111-115.
[18]
Greicius MD, Srivastava G, Reiss AL, et al. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A, 2004, 101(13):4637-4642.
[19]
Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol, 1997, 42(1):85-94.
[20]
Laureys S, Goldman S, Phillips C, et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. Neuroimage, 1999, 9(4):377-382.
[21]
Liao W, Zhang Z, Pan Z, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: A study combining fMRI and DTI. Hum Brain Mapp, 2010, DOI: 10.1002/hbm.21076.
[22]
邓小湘,蒋雯,王君,等.利用静息态功能磁共振成像研究缺血性脑卒中患者康复治疗后运动功能网络连接的变化.磁共振成像, 2010, 1(1):11-14.
[23]
Greicius MD, Krasnow B, Reiss AL, et al. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A, 2003, 100(1):253-258.

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