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• Clinical Article •
MRI findings of subcallosal 'dot-dash' sign in patients with opticospinal multiple sclerosis
CHEN Zhi-ye  LOU Xin  YANG Yang  MA Lin 

DOI:10.3969/j.issn.1674-8034.2011.04.005.


[Abstract] Objective: To evaluate the dignostic value of the subcallosal dot-dash sign in patients with opticospinal multiple slcerosis (OSMS).Materials and Methods: The sagittal thin slice T2-FLAIR images were obtained in 42 OSMS patients and 27 normal controls by using GE 3.0 T MR system. The subcallosal dot-dash sign was observed on mid-sagittal planes.Results: The positive rate for subcallosal dot-dash sign was 66.67% (28/42) in OSMS patients. The younger OSMS group (<50 years) had a higher positive rate (73.5%) for subcallosal dot-dash sign than older OSMS group (≥50 years) (37.5%). The subcallosal dot-dash sign was not seen in the normal controls.Conclusion: The subcallosal dot-dash sign on sagittal plane may be a relative characteristic MR findings for OSMS.
[Keywords] Opticospinal multiple sclerosis；Corpus callosum；Magnetic resonance imaging；Fluid attenuated inversion recovery

CHEN Zhi-ye Department of Radiology, PLA General Hospital, Beijing 100853, China

LOU Xin Department of Radiology, PLA General Hospital, Beijing 100853, China

YANG Yang Department of Neurology, PLA General Hospital, Beijing 100853, China

MA Lin* Department of Radiology, PLA General Hospital, Beijing 100853, China

*Correspondence to: Ma L, E-mail: cjr.malin@vip.163.com

Conflicts of interest   None.

Received  2011-05-25
Accepted  2011-06-14
DOI: 10.3969/j.issn.1674-8034.2011.04.005
DOI:10.3969/j.issn.1674-8034.2011.04.005.

[1]
Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology, 1996, 46(4): 907-911.
[2]
Kira J. Multiple sclerosis in the Japanese population. Lancet Neurol, 2003, 2(2): 117-127.
[3]
Cheng Q, Miao L, Zhang J, et al. A population-based survey of multiple sclerosis in Shanghai, China. Neurology, 2007, 68(18): 1495-1500.
[4]
Kira J, Kanai T, Nishimura Y，et al. Western versus Asian types of multiple sclerosis: immunogenetically and clinically distinct disorders. Ann Neurol, 1996, 40(4): 569-574.
[5]
Lisanti CJ, Asbach P, Bradley WG, Jr. The ependymal "Dot-Dash" sign: an MR imaging finding of early multiple sclerosis. AJNR Am J Neuroradiol, 2005, 26(8): 2033-2036.
[6]
Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Ann Neurol, 2011, 69(2): 292-302.
[7]
Kira J. Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis. Pathophysiology, 2011, 18(1): 69-79.
[8]
Kanzaki M, Mochizuki H, Ogawa G, et al. Clinical features of opticospinal multiple sclerosis with anti-aquaporin 4 antibody. Eur Neurol, 2008, 60(1): 37-42.
[9]
Eikelenboom MJ, Killestein J, Uitdehaag BM, et al. Opticospinal multiple sclerosis: a pathogenetically distinct form? Mult Scler, 2004, 10(3): 334-335.
[10]
Hashemi RH, Bradley WG, Jr., Chen DY, et al. Suspected multiple sclerosis: MR imaging with a thin-section fast FLAIR pulse sequence. Radiology, 1995, 196(2): 505-510.
[11]
Bakshi R, Ariyaratana S, Benedict RH, et al. Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions. Arch Neurol, 2001, 58(5): 742-748.
[12]
Gean-Marton AD, Vezina LG, Marton KI, et al. Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis. Radiology, 1991, 180(1): 215-221.
[13]
Horowitz AL, Kaplan RD, Grewe G, et al. The ovoid lesion: a new MR observation in patients with multiple sclerosis. AJNR Am J Neuroradiol, 1989, 10(2): 303-305.
[14]
Lehmann GL, Gradilone SA, Marinelli RA. Aquaporin water channels in central nervous system. Curr Neurovasc Res, 2004, 1(4): 293-303.
[15]
Pittock SJ, Weinshenker BG, Lucchinetti CF, et al. Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol, 2006, 63(7): 964-968.

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