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• Clinical Article •
Value of anti-aquaporin-4 antibody on Chinese patients with neuromyelitis optica
YANG Yang  WU Wei-ping  HUANG De-hui  WU Lei 

DOI:10.3969/j.issn.1674-8034.2011.04.006.


[Abstract] Objective: To determine the value of AQP4 antibody in Chinese patients with NMO, HR-NMO (High risk NMO) and classic multiple sclerosis (MS), and also to investigate clinical features and progonosis of patients with anti-AQP4 antibodies seropositive patients.Materials and Methods: Sera of patients with NMO, HR-NMO and MS were all investigated for the presence of AQP4 antibody by indirect immunofluorescence using human AQP4-transfected cells. The diagnositic and prognositic value of anti-AQP4 antibody were evaluated in 210 patients with NMO (n=53), HR-NMO (n=42) including optico-spinal MS (OSMS), longitudinally extensive transverse myelitis (LETM), recurrent ON (RON) and ON or TM with other antoimmune disease, classic MS (n=86), and other neurological diseases (n=29).Results: In our study, the anti-AQP4 antibody’s seropositivity in the NMO group was 71%, and the specificity was 91%. There were significant differences among NMO, HR-NMO and MS with respect to AQP4 antibody (P<0.05). Also, there were significant differences between the NMO/HR-NMO and MS group with respect to sex, accompanying with severe ON, TM, brain MRI normal, spinal-cord lesion having more than 3 segments, and anti-AQP4 antibody positive (P<0.05). And 36 (66.7%) of 55 seropositive patients were found to present with severe ON, 41 (75.9%) with TM, 30 (55.6%) with spinal-cord lesion >3 segments, 8 (14.8%) develop to ON relapse and 19 (35.2%) TM relapse within 24 median months follow-up. There were significantly differences between seropositive and seronegative patiets with respect to accompanying with severe ON, TM, spinal-cord lesion >3 segments, developing to ON relapse and TM relapse (P<0.05).Conclusion: AQP4 antibody is a sensitive and specific biomarker for discrimination between NMO, MS and other neurological diseases.
[Keywords] Neuromyelitis optica；Multiple sclerosis；Aquaporin；NMO-IgG；Central nervous system

YANG Yang Department of Neurology, General Hospital of Chinese PLA, Beijing 100853, China

WU Wei-ping* Department of Neurology, General Hospital of Chinese PLA, Beijing 100853, China

HUANG De-hui Department of Neurology, General Hospital of Chinese PLA, Beijing 100853, China

WU Lei Department of Neurology, General Hospital of Chinese PLA, Beijing 100853, China

*Correspondence to: Wu WP, E-mail: wuwp@vip.sina.com

Conflicts of interest   None.

Received  2011-05-25
Accepted  2011-06-15
DOI: 10.3969/j.issn.1674-8034.2011.04.006
DOI:10.3969/j.issn.1674-8034.2011.04.006.

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