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• Clinical Article •
Susceptibility-weighted imaging and dynamic susceptibility contrasted MR perfusion imaging of normal-appearing white matter around plaques in multiple sclerosis
MIAO Yan-wei  WEI Qiang  HAN Rui  ZHANG Jing-wen  LANG Zhi-jin 

DOI:10.3969/j.issn.1674-8034.2011.04.007.


[Abstract] Objective: To determine the correlation between iron deposit and perfusion by quantificationally measuring the phase value and perfusion indices in normal-appearing white matter (NAWM) in multiple sclerosis (MS) patients.Materials and Methods: Thirty-one clinically proven MS cases were performed with susceptibility-weighted imaging (SWI) and dynamic susceptibility contrasted MR perfusion imaging (DSC-PI). Thirty age-matched healthy volunteers were participated in this study as a control. Features of MS plaques in filtered phase images (FPI) were first assessed. The measurements of phase values and perfusion parameters (including CBF and CBV) were taken and compared by using paired t test, and the correlations between phase values and perfusion parameters, as well as phase values and EDSS was respectively evaluated by using Pearson correlative analysis.Results: In 31 cases of MS, the round or oval hypointense foci with or without small veins were considered as the characteristic finding of MS plaques. In comparison with the controls, the phase values of NAWM surrounding MS plaques were significantly lower in the MS group (P<0.05). Pearson correlation analysis revealed a significant correlation between the phase values of bilateral parietal NAWM and EDSS (P<0.05). As for the bilateral parietal and frontal NAWM, their phase values also significantly correlated with the rCBF (P<0.05).Conclusion: The phase values of NAWM in the MS patients varied with the cerebral perfusion, which also correlated with the EDSS, and could be used to evaluate the course changes of MS patients.
[Keywords] Multiple sclerosis；Normal-appearing white matter；Magnetic resonance imaging；Susceptibility-weighted imaging；Perfusion

MIAO Yan-wei* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

WEI Qiang Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

HAN Rui Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

ZHANG Jing-wen Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LANG Zhi-jin Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Correspondence to: Miao YW, E-mail: ywmiao716@yahoo.com.cn

Conflicts of interest   None.

Received  2011-02-21
Accepted  2011-05-24
DOI: 10.3969/j.issn.1674-8034.2011.04.007
DOI:10.3969/j.issn.1674-8034.2011.04.007.

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