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• Clinical Article •
Improved visibility of the subthalamic nucleus in PD patients using susceptibility-weighted imaging: a preliminary study
ZHANG Jing  ZHANG Yun-ting  HE Ning  CHEN Jing  HE Ya-na 

DOI:10.3969/j.issn.1674-8034.2011.05.007.


[Abstract] Objective: To evaluate the visibility of the subthalamic nucleus (STN) using susceptibility-weighted imaging (SWI) for Parkinson's disease (PD).Materials and Methods: Twenty PD patients were collected and examined with MRI to visualize the STN. Scanning protocols included SWI, T2-weighted fast spin-echo images (FSE) in axial and coronal plane and high-resolution T1WI images in axial plane. According to the signal contrast and border sharpness between STN and structures, the images were classified to four grades (grade 0, 1, 2, 3) by experienced radiologist. The visibility of STN was evaluated in the three protocols.Results: In SWI images, the STNs of 18 cases (90%) were classified to grade 2-3 which clearly visualized as hypointense, biconvex lens-shaped structure. In T2WI images, the STNs of 4 cases (20%) couldn't be identified as grade 0. Thirteen cases (65%) showed hypointense but poor contrast as grade 1, only 3 cases (15%) were clearly visualized as grade 2-3. In T1WI images, the STNs of 18 cases (90%) couldn't be identified as grade 0. Only 2 cases (10%) showed but poor contrast as grade 1. Significant difference was found among three protocols. Significant differences were found between T1WI and T2WI, T2WI and SWI.Conclusion: Compared to T1WI and T2WI, SWI improves the visibility of the STN. It may be a promising technique to accurately localizes the STN for precise surgical targeting.
[Keywords] Susceptibility-weighted imaging；Subthalamic nucleus；Deep brain stimulation

ZHANG Jing Department of Magnetic Resonance Imaging, the Second Hospital of Lanzhou Unervisity, Lanzhou 730030, China

ZHANG Yun-ting* Department of Radiology, General Hospital of Tianjin Medical Unervisity, Tianjin 300052, China

HE Ning Department of Radiology, General Hospital of Tianjin Medical Unervisity, Tianjin 300052, China

CHEN Jing Department of Radiology, General Hospital of Tianjin Medical Unervisity, Tianjin 300052, China

HE Ya-na Department of Radiology, General Hospital of Tianjin Medical Unervisity, Tianjin 300052, China

*Correspondence to: Zhang YT, E-mail: cjr.zhangyunting@vip.163.com

Conflicts of interest   None.

Received  2011-04-08
Accepted  2011-06-12
DOI: 10.3969/j.issn.1674-8034.2011.05.007
DOI:10.3969/j.issn.1674-8034.2011.05.007.

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