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Application of superparamagnetic iron oxide nanoparticles as contrast agents in brain magnetic resonance imaging
ZHANG Bao-lin  ZHANG Hui-yang 

DOI:10.3969/j.issn.1674-8034.2011.05.012.


[Abstract] Superparamagnetic iron oxide nanoparticles have a variety of biomedical applications because of their magnetic property and biocompatibility. The basic principles and parameters of the magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) are presented. Recent advances of iron oxide nanoparticles with various properties acting as MRI contrast agents are described. The iron oxide nanoparticles modified or conjugated with monoclonal antibodies, proteins, peptides, nucleotides, and other particular polymers, are taken up specifically, and can be used as contrast agents in MRI to enhance detection of neurodegenerative diseases, to monitor targeted drug delivery and therapeutic processes, and to image targeted biomolecules or cells; Iron oxide nanoparticles coated with dextran or polyethylene glycol (PEG) have long blood half-life, and are used as fMRI contrast agents to measure haemodynamic changes after enhanced neural activity. Further studies are needed on the control of particle sizes and the physicochemical properties of the modifications, increase of crystallinity and consequently saturation magnetization, conjugation with different targeting substances, the development of hybrid nanoparticles with optical and magnetic properties, and comprehension of the interactions between the nanoparticles and biomolecules, cells and tissues.
[Keywords] Superparamagnetic iron oxide nanoparticles；Contrast agents；Magnetic resonance imaging；Brain

ZHANG Bao-lin* School of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China

ZHANG Hui-yang Department of Radiology, Affiliated Hospital of Guilin Medical College, Guilin, 541001, China

*Correspondence to: Zhang BL, E-mail: zhangbaolin@glite.edu.cn

Conflicts of interest   None.

Received  2011-03-04
Accepted  2011-07-01
DOI: 10.3969/j.issn.1674-8034.2011.05.012
DOI:10.3969/j.issn.1674-8034.2011.05.012.

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