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• Clinical Article •
Imaging findings in four patients with hepatic veno-occlusive disease
LI Yun-fang  LI Hong-jun 

DOI:10.3969/j.issn.1674-8034.2011.06.005.


[Abstract] Objective: To discuss the imaging characteristics of the hepatic veno-occlusive disease (HVOD).Materials and Methods: Four cases of HVOD were retrospectively analyzed. Each of the case was scanned by MRI in 3 dynamic phases after contrast enhancement and ultrasound. Three of the 4 cases were also dynamically scanned CT. The analysis was focused on the dynamic change of the parenchyma and the vasculature system and compared with that of pre-contrast images.Results: Two cases were diagnosed by biopsy with the other 2 confirmed by clinical signs. On pre-contrast MR images, enlarged liver, seroperitoneum, and heterogenous signal intensities of the parenchyma were revealed. On post-contrast images, the liver demonstrated nonhomogenous enhancement in arterial phase, patchy enhancement and low-perfusion in portal vein phase, and slow wash-out in delayed phase. The dynamic change on CT images was similar with that of MRI. All of the cases revealed non-obstructive hepatic veins and inferior vena cava in ultrasound examination.Conclusions: The findings of HVOD were non-specific in ultrasound, pre-contrast MR images, and pre-contrast CT. The signs of dynamic contrast images were more valuable for the diagnosis.
[Keywords] Hepatic veno-occlusive disease；Magnetic resonance imaging；Diagnosis

LI Yun-fang Department of Radiology, Capital Medical University, Beijing You'an Hospital, Beijing 100069, China

LI Hong-jun* Department of Radiology, Capital Medical University, Beijing You'an Hospital, Beijing 100069, China

*Correspondence to: Li HJ, E-mail: lihongjun00113@126.com

Conflicts of interest   None.

Received  2011-09-30
Accepted  2011-11-09
DOI: 10.3969/j.issn.1674-8034.2011.06.005
DOI:10.3969/j.issn.1674-8034.2011.06.005.

[1]
Simon M, Hahn T, Ford LA, et a1. Retrospective multivariate analysis of hepatic veno-occlusive disease after blood or marrow transplantation：possible beneficial use of low molecular weight heparin．Bone Marrow Transplant, 200l, 27(6):627-633.
[2]
Jones RJ, Lee KS, Beschorner WE, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation,1987, 44(1):778-783•
[3]
Shulman HM, Hinterberger W. Hepatic veno-occlusive disease liver toxicity syndrome after bone marrow transplantation.Bone Marrow Transplant, 1992, 10(3):197-214.
[4]
Wadleigh M, Ho V, Momtaz P, et al. Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment. Curr Opin Hematol, 2003, 10(6):451-462．
[5]
Hill KR, Rhodes K, Stafford JL, et al. Serous hepatosis: a pathogenesis of hepatic fibrosis in Jamaican children. Br Med J, 1953, 1(4802):117-122.
[6]
Prakash AS, Pereira TN, Reilly PE, et al. Pyrrolizidine alkaloids in human diet. MutatRes, 1999, 443(1-2):53-67.
[7]
Carreras E, Bertz H, Arcese W, et al. Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European group for blood and marrow transplantation. Blood, 1998, 92(10):3599-3604.
[8]
Brisse H, Orbach D, Lassau N, et al. Portal vein thrombosis during antineoplastic chemotherapy in children: Report of five cases and review of the literature. Eur J of Cancer, 2004, 40(18):2659-2666.
[9]
Deleve LD, Ito Y, Bethea NW, et al. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. AM J Physiol Gastrointest Liver Physiol, 2003, 284(6):1045-1052.
[10]
McDonald OB. Hinds MS, Fisher LD, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation:a cohort study of 355 patients. Ann Inter Med, 1993, 118(4):225-267.
[11]
Deleve LD. Cellular target of cyclophosphamide toxicity in the munne liver: role of glutathione and site of metabolic activation. Hepatol, 1996, 24(4):830-837.
[12]
Bras G, Hill KR. Veno-occlusive disease of the liver, essential pathology. Lancet, 1956, 28(271):161-163.
[13]
Chen YP, Li J, Chai JA, et al. Clinical and pathoIogic study on hepatic veno-occlusive disease.Chin J Dig, 2006, 26(4):224-226.
[14]
Jiang TA, Weng HH, Ao Jian-yang, et al. Significance of ultrasonography in diagnosing hepatic sinusoidal abstructive syndrome. Chin J Ultrasound, 2008, 24(10):951-954.
[15]
Zhang GH, Kong AZ, Fang JW, et al. CT imaging of hepatic veno-occlusive disease(an analysis 14 cases). Chin J Radiology, 2006, 40(3):250-253.
[16]
Dumont Ch, Lambert M, Van Beers BE．MR imaging findings in a patient with hepatic veno-occlusive disease．Acta Gastroenteml Belg，2004, 67(2):236-238．
[17]
Yang JJ, Hu CH, HE J. The contrast of ultrasound and CT in diagnosis of hepatic veno-occlusive disease. J Med Imaging (china), 2010, 20(9):1381-1385.

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