Share：
Share this content in WeChat
X
[Chinese][PDF]72064
• Clinical Article •
Clinic value of susceptibility weighted imaging in the detection of cerebral microbleeds
LIU De-guo  YU Tai-fei  WANG Guang-bin  ZHAO Bin 

DOI:10.3969/j.issn.1674-8034.2011.06.006.


[Abstract] Objective: To evaluate the clinic value of cerebrovasccular in susceptibility weighted imaging (SWI) in the detection of cerebral microbleeds (CMBs).Materials and Methods: The study sample consisted of 172 patients. SWI was used to detect the CMBs number, location and investigate their association with clinic parameter, lacunar infarction and white mattet change.Results: Significant correlations between microbleeds and age, hypertension, blood pressure, lacunar infarction, white matter change were observed. Systolic pressure was found closely associated with CMBs in patients with and without hypertension. In addition, a significant correlation between the severity of CMBs and that of lacunar infarction, as well as white matter changes was noted.Conclusion: SWI is a valuable tool in detecting microbleeds for the prevention and treatment of cerebrovasccular diseases.
[Keywords] Cerebral microbleeds；Susceptibility weighted imaging (SWI)；Hypertension；Aspirin

LIU De-guo Shandong Medical Imaging Research Institute, Jinan 250021, China

YU Tai-fei Shandong Medical Imaging Research Institute, Jinan 250021, China

WANG Guang-bin Shandong Medical Imaging Research Institute, Jinan 250021, China

ZHAO Bin* Shandong Medical Imaging Research Institute, Jinan 250021, China

*Correspondence to: Zhao B, E-mail: cjr.zhaobin@vip.163.com

Conflicts of interest   None.

Received  2011-02-21
Accepted  2011-05-24
DOI: 10.3969/j.issn.1674-8034.2011.06.006
DOI:10.3969/j.issn.1674-8034.2011.06.006.

[1]
Offenbacher H, Fazekas F, Schmidt R, et al. MR of cerebral abnormalities concomitant with primary intracerebral hematomas. AJNR Am J Neuroradiol, 1996, 17(3): 573-578.
[2]
Staals J, van Oostenbrugge RJ, Knottnerus IL, et al. Brain Microbleeds Relate to Higher Ambulatory Blood Pressure Levels in First-Ever Lacunar Stroke Patients. Stroke, 2009, 40(10): 3264-3268.
[3]
Nishikawa T, Ueba T, Kajiwara M, et al. Cerebral microbleeds predict first-ever symptomatic cerebrovascular events. Clin Neurol Neurosurg, 2009, 111(10): 825-828.
[4]
Naka H, Nomura E, Takahashi T, et al. Combinations of the presence or absence of cerebral microbleeds and advanced white matter hyperintensity as predictors of subsequent stroke types. AJNR Am J Neuroradiol, 2006, 27(4): 830-835.
[5]
Aharon-Peretz J, Cummings VL, Hill MA, et al. Vascular dementia and dementia of the Alzheimer type. Arc Neuro, 1988, 45(7): 719-721.
[6]
Reichenbach JR, Venkatesan R, Schillinger DJ, et al. Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology, 1997, 204(1): 272-277.
[7]
Liu DG, Zhao B. Clinical application and update of susceptibility weighted imaging (SWI) in central nervous system. J Med imaging, 2010, 11(20): 1716-1718.
[8]
Babikian T, Freier MC, Tong KA, et al. Susceptibility weighted imaging: neuropsychologic outcome and pediatric head injury. Pediatr Neurol, 2005, 33(3): 184-194.
[9]
Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds, systematic review, subgroup analyses and standards for study design and reporting. Brain, 2007, 130(8): 1988-2003.
[10]
Igase M, Tabara Y, Igase K, et al. Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association with Asymptomatic Lacunar Infarction. Stroke, 2009, 73(3): 530-533.
[11]
Gregoire SM, Brown MM, Kallis C, et al. MRI Detection of New Microbleeds in Patients with Ischemic Stroke Five-Year Cohort Follow-up Study. Stroke, 2010, 41(1): 184-186.
[12]
Sun J, Soo YO, Lam WW, et al. Different Distribution Patterns of Cerebral Microbleeds in Acute Ischemic Stroke Patients with and without Hypertension. Eur Neurol, 2009, 62(5): 298-303.
[13]
Nakata-KudoY, Mizuno T, Yamada K, et al. Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease. Dement Geriatr Cogn Disord, 2006, 22(1): 8-14.
[14]
Vernooij MW, Vander LA, Ikram MA, et al. Prevalence and risk factors of cerebral microbleeds: The Rotterdam Scan Study. Neurology, 2008, 70(14): 1208-1214.
[15]
Roob G, Lechner A, Schmidt R, et al. Frequency and location of microbleeds in patients with primary intracerebral hemorrhage. Stroke, 2000, 31(11): 2665-2669.
[16]
Lee S, Bae H, Kwon S, et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology, 2004, 62(1): 72-76.
[17]
Wardlaw JM, Lewis SC, Keir SL, et al. Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions. Stroke, 2006, 37(10): 2633-2636.
[18]
Liu PF, Cui YZ, Na J, et al. Cerebral microbleeds-prevalence, distribution and risk factors in northeast population without preceding large-area stroke. Chin Med J (Engl), 2010,123(3): 286-290.
[19]
Tokuda Y, Kato J. Aspirin and risk of hemorrhagic stroke. JAMA, 1999, 282(8): 732-733.
[20]
Gregoire SM, Jäger HR, Yousry TA, et al. Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: hospital-based, caseecontrol study. J Neurol Neurosurg Psychiatry, 2010, 81(6): 679-684.
[21]
Stegmayr B, Asplund K. Diabetes as a risk factor for stroke. A population perspective. Diabetologia, 1995, 38(9): 1061-1068.
[22]
Tsushimaa Y, Aokib J, Endob K. Brain microhemorrhage detected on T2 weighted gradient echo MR images. AJNR Am J Neuroradiol, 2003, 24(1): 88-96.
[23]
Ueno H, Naka H, Ohshita T, et al. Association between cerebral microbleeds on T2*-weighted MR images and recurrent hemorrhagic stroke in patients treated with warfarin following ischemic stroke. AJNR Am J Neuroradiol, 2008, 29(8): 1483-1486.
[24]
Nighoghossian N, Hermier M, Adeleine P, et al. Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke, 2002, 33(3): 735-742.

PREV Imaging findings in four patients with hepatic veno-occlusive disease
NEXT MR diffusion imaging of femoral head and neck in healthy adults
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn