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• Original Article •
Application of DWI for early diagnosis of spinal tuberculosis in Rabbits
LIU Ying  WANG Yun-ling  WANG Hong  WANG Hao  LIU Bo  JIA Wen-Xiao 

DOI:10.3969/j.issn.1674-8034.2011.06.009.


[Abstract] Objective: To discuss application of diffusion weighted imaging for early diagnosis of spinal tuberculosis in rabbits.Materials and Methods: Twenty-five healthy New Zealand rabbits were selected in this study. Firstly, animal models of spinal tuberculosis were made by operation, then they were examined with common MRI and DWI at 4 weeks, 6 weeks, 8 weeks respectively. MRI manifestations and normal vertebral and pathological changes of vertebral ADC values were analyzed by using two groups of F-test.Results: The spinal tuberculosis model was successfully established in rabbits. Vertebral and intervertebral disc has not seen the apparently unusual at 4 week, 6 weeks, 8 weeks, but DWI appear unusual signal. The difference between the mean ADC values of normal vertebral and lesions vertebral was significance, ADC values of lesions vertebral was higher than normal vertebral. Pathological findings confirmed tuberculosis.Conclusions: Diffusion weighted imaging is useful to the early diagnosis of spinal tuberculosis.
[Keywords] Rabbits；Spinal tuberculosis；Diffusion weighted imaging；Magnetic resonance imaging

LIU Ying Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

WANG Yun-ling Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

WANG Hong Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

WANG Hao Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

LIU Bo Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

JIA Wen-Xiao* Imaging Center, The Sceond Affiliated Hospital of Xinjiang Medical University, Urumiqi 830063, China

*Correspondence to: Jia WX, E-mail: jwxxj@sina.com

Conflicts of interest   None.

Received  2011-09-20
Accepted  2011-10-31
DOI: 10.3969/j.issn.1674-8034.2011.06.009
DOI:10.3969/j.issn.1674-8034.2011.06.009.

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