Share：
Share this content in WeChat
X
[Chinese][PDF]81871
• Original Article •
BOLD MRI of rat kidney changes during acute unilateral ureteral obstruction at 3.0 T
XING Jin-zi  LIU Ai-lian  SONG Qing-wei  YANG Chun-yang 

DOI:10.3969/j.issn.1674-8034.2011.06.010.


[Abstract] Objective: To evaluate the renal oxygenation changes during acute unilateral ureteral obstruction in rats using blood oxygen level-dependent MR imaging (BOLD MRI) in 3.0 T MR.Materials and Methods: Sixteen healthy SD rats, 3 rats died because of anesthesia, 13 rats were performed kidney T2WI and coronal BOLD imaging respectively before UUO, 1 hour after UUO and 1 hour after release of UUO. Observed the signal and anatomical structure changes among the different groups of renal cortex and medulla, compared the SNR of renal parenchyma among three groups. BOLD images were reconstructed on 4.4 workstation, R2* values were determined in the cortex and medulla of the obstructed and the contralateral nonobstructed kidneys, then comparative analysis of R2* values of renal cortex and medulla among different groups. Compared with the rate of R2* values changes between the mild obstruction and severe obstruction; Analyze the relationship of relief group and no relief group with obstructions and R2* changes.Results: The SNR between left and right renal were the same, and renal anatomy was showed clearly before UUO. After UUO the SNR of 13 rats affected side renal was significantly higher than before, the boundaries of cortex and medulla show blurry, and the pelviectasis in varying degrees. After release of UUO, the SNR higher than the obstruction former group, lower than the obstruction group, the boundaries got clearly, and the renal pelvis recovery in varying degrees. Before UUO, the R2* values of medulla was significantly higher than that of renal cortex, but during the UUO was associated with a decreased R2* in medulla, and after release of obstruction the medulla R2* were increased slowly. The R2* showed no statistical difference in the cortex and nonobstructed kidneys among three groups. The rates of R2* change in mild obstruction slightly less than in severe obstruction. The obstruction and the R2* changes in relief group were lower than those in no relief group.Conclusions: 3.0 T BOLD MRI provides a useful tool in UUO which is associated with altered renal oxygen consumption.
[Keywords] Magnetic resonance imaging；Renal；Acute unilateral ureteral obstruction；Blood oxygen level-dependent

XING Jin-zi Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Ai-lian* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

SONG Qing-wei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

YANG Chun-yang Dalian Medical University, Dalian 116011, China

*Correspondence to: Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

Received  2011-07-02
Accepted  2011-10-20
DOI: 10.3969/j.issn.1674-8034.2011.06.010
DOI:10.3969/j.issn.1674-8034.2011.06.010.

[1]
Moe OW. Kidney stones: pathophysiology and medical management. Lancet, 2006, 367(9507): 333-344. DOI: .
[2]
Epstein FH. Oxygen and renal metabolism. Kidney Int, 1997, 51(2): 381-385.
[3]
Brezis M, Rosen S, Silva P, et al. Renal ischemia:a new perspective. Kidney Int, 1984, 26(10): 375-383.
[4]
Djamali A, Sadowsk EA, Muehrer RJ, et al. BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allorgraft dysfunction. Am J Physiol Renal Physiol, 2007, 292(2): 513-522.
[5]
Tjandra T, Brooks JC, Figueired P, et al. Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging:implications for clinical trial design. NeuroImage, 2005, 27(2):393-401.
[6]
Poser BA, Norris DG. Fast spin echo sequences for BOLD functional MRI. Magn Reson Mater Phy, 2007, 20(1): 11-17.
[7]
Pedersen M, Dissing TH, Morkenborg J, et al. Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction. Kidney Int, 2005, 67(6): 2305-2312.
[8]
Harriet C, Thomas M, Sonia S, et al. Renal oxygenation changes during acute unilateral ureteral obstruction: assessment with blood oxygen level-dependent MRI-initial experience. Radiology, 2008, 247(3): 754-761.
[9]
Yang XD, Cao J, Wang XY, et al. Blood oxygen level-dependent MR imaging of rat kidney at 3.0 TMR scanner:initial experience. Chin J Med Imaging Technol, 2007, 23(6): 809-811.
[10]
Jensen AM, Nørregaard R, Topcu SO, et al. Oxygen tension correlates with regional blood flow in obstructed rat kidney. J Exp Biol, 2009, 212(19):3156-3163.
[11]
Liu YP, Liang CH, Zhang SX, et al. Experimental study of renal damage assessment after injection of iodine contrast medium:the role of blood oxygen level-dependent functional MRI with a 3.0 T system. Chin J Radiol, 2010, 44(8): 872-876.

PREV Application of DWI for early diagnosis of spinal tuberculosis in Rabbits
NEXT Whole-Body MR/PET hybrid imaging: technical considerations, clinical workflow, and initial results
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn