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• Clinical Article •
Preliminary study of multivoxel 1H-MR spectroscopy in patients with moderate to severe obstructive sleep apnea hypopnea syndrome pre-and post-uvulopalatopharyngoplasty
HAO Cai-xian  LIU Jun  LIU Xue-huan  XU Liang  WANG Jin-yue  ZHONG Jin  ZHU Miao 

DOI:10.3969/j.issn.1674-8034.2012.01.003.


[Abstract] Objective: To investigate the clinical usage of multivoxel 1H magnetic resonance spectroscopy (1H-MRS) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) pre-and post-uvulopalatopharyngoplasty (UPPP).Materials and Methods: Twenty cases of moderate to severe OSAHS underwent UPPP and performed brain multivoxel 1H-MRS examinations in pre-and post-operation. The ratios of brain metabolites of centrum ovale and basal ganglia were recorded and analyzed, respectively.Results: In the centrum ovale, the postoperative NAA/Cr and NAA/Cho of 2.422±0.265 and 1.487±0.168 was significantly higher than that of the preoperative (2.199±0.143 and 1.163±0.170, P<0.05). The postoperative Cho/Cr (1.580±0.175) significantly decreased than that of the preoperative (1.768±0.113, P<0.05). In the basal ganglia, postoperative NAA/Cr, NAA/Cho (1.995±0.131 and 1.673±0.155, respectively) was slightly increased than that of the preoperative (1.932±0.155 and 1.568±0.141). The the postoperative Cho/Cr of 1.181±0.129 decreased than that of the preoperative (1.262±0.134), but the difference was not significant (P> 0.05).Conclusion: Multivoxel 1H-MRS may be useful for brain metabolism in patients with OSAHS pre-and post-UPPP.
[Keywords] Obstructive sleep apnea hypopnea syndrome；Multivoxel 1H magnetic resonance spectroscopy；Cerebral metabolism；Uvulopalatopharyngoplasty

HAO Cai-xian Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

LIU Jun* Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

LIU Xue-huan Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

XU Liang Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

WANG Jin-yue Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

ZHONG Jin Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

ZHU Miao Department of Radiology, Tianjin Union Medical Centre, Tianjin 300121, China

*Correspondence to: Liu J, E-mail:cjr.liujun@vip.163.com

Conflicts of interest   None.

Received  2011-12-12
Accepted  2012-01-06
DOI: 10.3969/j.issn.1674-8034.2012.01.003
DOI:10.3969/j.issn.1674-8034.2012.01.003.

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