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• Clinical Article •
Comparative study of MRI characteristics between posterior reversible encephalopathy syndrome and MELAS syndrome
TANG Qun-feng  WU Li-yuan  CHEN Hong-wei  XUE Yu-xi  CHENG Wei-jing  XUE Jing  SHEN Jun-kang 

DOI:10.3969/j.issn.1674-8034.2012.01.007.


[Abstract] Objective: To compare the MRI characteristics of posterior reversible encephalopathy syndrome with that of MELAS syndrome.Materials and Methods: Twenty-one patients with PRES and 6 patients with MELAS syndrome were recruited. MRI findings, including the location, signal intensity, and functional characteristics, were retrospectively analyzed.Results: Lesions in the subcortical white matter were found in 21 patients with PRES, and involved cortex in 13 patients. Lesions located in the cortex and subcortical were revealed in 6 patients with MELAS. On DWI, low signal intensity was revealed in 19 patients with PRES; high signal intensity was shown in acute MELAS with isointensity in remission. Decreased cerebral blood volume (CBF) was found in 2 cases of PRES. Increased CBF in 2 cases of MELAS syndrome.Conclusion: Detailed MRI analysis is helpful for the differentiation of PRES and MELAS syndrome.
[Keywords] Posterior reversible encephalopathy syndrome；MELAS syndrome；Magnetic resonance imaging；Comparative study

TANG Qun-feng Department of Radiology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

WU Li-yuan Department of Radiology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

CHEN Hong-wei * Department of Radiology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

XUE Yu-xi Department of Neurology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

CHENG Wei-jing Department of Neurology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

XUE Jing Department of Radiology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China

SHEN Jun-kang Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China

*Correspondence to: Chen HW, E-mail: chw6312@163.com

Conflicts of interest   None.

Received  2011-12-04
Accepted  2012-01-04
DOI: 10.3969/j.issn.1674-8034.2012.01.007
DOI:10.3969/j.issn.1674-8034.2012.01.007.

[1]
Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med, 1996, 334(26): 494-500.
[2]
Bartynski WS, Tan HP, Boardman JF,et al. Posterior reversible encephalopathy syndrome after solid organ transplantation. AJNR Am J Neuroradiol, 2008, 29(5): 924-930.
[3]
Hodnett P, Coyle J, O'Regan K, et al. PRES (posterior reversible encephalopathy syndrome), a rare complication of tacrolimus therapy. Emerg Radiol, 2009, 16(6): 493-496.
[4]
Hamano T, Takeda T, Morita H,et al. Posterior reversible encephalopathy syndrome following measles vaccination. J Neurol Sci, 2010, 298(1-2): 124-126. DOI: .
[5]
Iizuka T, Sakai F. Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. Curr Neurovasc Res, 2005, 2(1): 29-45.
[6]
谢晟，齐朝月，肖江喜, 等. MELAS患者脑灌注异常的MRI特征. 中华放射学杂志, 2008, 42(5): 471-473.
[7]
Hefzy HM, Bartynski WS, Boardman JF, et al. Hemorrhage in posterior reversible encephalopathy syndrome: imaging and clinical features. AJNR Am J Neuroradiol, 2009, 30(7): 1371-1379.
[8]
Lee VH, Wijdicks EFM, Manno EM, et al. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol, 2008, 65(2): 205-210.
[9]
王光彬，单瑞芹，赵斌, 等. 脑后部可逆性脑病综合征的CT、MRI诊断. 中华放射学杂志, 2006, 40(9): 908-912.
[10]
林洁，朱雯华，汪寅, 等. 线粒体脑肌病伴高乳酸血症和卒中样发作22例神经影像学特点分析. 中华神经科杂志, 2007, 40(11): 728-731.
[11]
Ito H, Mori K, Harada M, et al. Serial brain imaging analysis of stroke-like episodes in MELAS. Brain Dev, 2008, 30(7): 483-488.
[12]
王志群，李坤成，武力勇, 等. 脑后部可逆性脑病综合征的MRI及DWI特点.放射学实践, 2009, 24(8): 828-831.
[13]
韩顺昌，张辉，郭阳, 等. 可逆性后部白质脑病综合征的临床及影像学特点. 临床神经病学杂志, 2007, 20(3): 161-163.
[14]
Schwartz R, Mulkern R, Vajapeyam S, et al. Catheter angiography, MR angiography, and MR perfusion in posterior reversible encephalopathy syndrome. AJNR AMJ Neuroradiol, 2009, 30(2): E19.
[15]
Feng F, You H, Gao J, et al. Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy. Chin Med Sci J, 2006, 21 (4): 234-238.
[16]
黄文才，汤群锋，李国雄, 等. 线粒体脑肌病卒中样病灶的磁共振诊断及波谱分析. 实用放射学杂志, 2010, 26(4): 457-461.
[17]
Kwon S, Koo J, Lee S. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Pediatr Neurol, 2001, 24(5): 361-364.

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