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• Original Article •
Study of magnetic resonance imaging at 1.5 Tesla based on pH-sensitive magnetization transfer technology
WEI Mao-bin  SHEN Zhi-wei  XIAO Gang  QIU Qing-chun  CHEN Yao-wen  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2012.01.010.


[Abstract] Objective: To investigate the feasibility of magnetization transfer (MT) technology in application of magnetic resonance pH imaging on 1.5 T clinical MR scanner.Materials and Methods: Two groups of agarose-creatine pH phantoms were prepared and imaged by improved spin-echo-magnetization transfer pulse sequence.Results: At radiofrequency offset of 224 Hz, the signal intensity magnetization transfer image of same pH phantoms showed no difference. The signal intensity of different pH phantoms depended on pH values. The higher pH was, the stronger signal intensity was.Conclusions: pH-sensitive magnetization transfer image can be acquired by improving the parameters and choosing appropriate radiofrequency offset of spin-echo-magnetization transfer pulse sequence on clinical 1.5 T MR scanner. This experimental study laid a solid foundation for further clinical applications.
[Keywords] Magnetization transfer imaging；pH；Frequency offset

WEI Mao-bin Medical Imaging, the 2nd Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

SHEN Zhi-wei Medical Imaging, the 2nd Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

XIAO Gang Department of mathematics and information technology, Hanshan Normal College, Chaozhou 521041, China

QIU Qing-chun Department of physics and information, Shantou University Medical College, Shantou 515041, China

CHEN Yao-wen Central laboratory, Shantou University, Shantou 515063, China

WU Ren-hua * Medical Imaging, the 2nd Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: rhwu@stu.edu.cn

Conflicts of interest   None.

Received  2011-12-08
Accepted  2012-01-04
DOI: 10.3969/j.issn.1674-8034.2012.01.010
DOI:10.3969/j.issn.1674-8034.2012.01.010.

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