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• Original Article •
Comparative study of MRI R2* with different ROI measurement in iron-overloaded liver
HU Su  HU Chun-hong  ZHANG Jing-gang  ZHANG Min-ge  WANG Fang-fang  XING jian-ming  CHEN jian-hua 

DOI:10.3969/j.issn.1674-8034.2012.01.011.


[Abstract] Objective: To compare the differences of two kinds of ROI measurements of MRI liver R2* with iron overload.Materials and methods: Thirty-two adult healthy New Zealand rabbits were randomly divided into 4 groups, with 3 groups received intravenous injection of Iron Sucrose with different concentrations every 1 week for 4 weeks. After liver scan was performed by 3.0T MR scanner with 2D MFGRE sequence, the animals were sent for LIC assessment immediately. The R2* value were measured on R2* Map with whole liver and small region-of interest (ROI) selection by 2 observers, independently. The R2* value was compared between intra-and inter-observer; from the whole liver and the ROI, respectively.Results: The data from 2 types of measurement was consistent (P>0.05, ICC=0.99). The R2* value measured from the whole liver was smaller than that of ROI selection (P<0.05).Conclusion: To analyze the over-loaded liver by MRI R2*, the whole liver measurement is superior to the ROI positioning.
[Keywords] Region-of-interest；R2* value；Magnetic resonance imaging；Iron overload

HU Su Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

HU Chun-hong * Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

ZHANG Jing-gang Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

ZHANG Min-ge Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

WANG Fang-fang Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

XING jian-ming Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

CHEN jian-hua Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

*Correspondence to: Hu CH, E-mail: hch5305@163.com

Conflicts of interest   None.

Received  2011-10-26
Accepted  2011-12-11
DOI: 10.3969/j.issn.1674-8034.2012.01.011
DOI:10.3969/j.issn.1674-8034.2012.01.011.

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