Share：
Share this content in WeChat
X
[Chinese][PDF]706118
• Original Article •
Comparative study of MRI R2* with different ROI measurement in iron-overloaded liver
HU Su  HU Chun-hong  ZHANG Jing-gang  ZHANG Min-ge  WANG Fang-fang  XING jian-ming  CHEN jian-hua 

DOI:10.3969/j.issn.1674-8034.2012.01.011.


[Abstract] Objective: To compare the differences of two kinds of ROI measurements of MRI liver R2* with iron overload.Materials and methods: Thirty-two adult healthy New Zealand rabbits were randomly divided into 4 groups, with 3 groups received intravenous injection of Iron Sucrose with different concentrations every 1 week for 4 weeks. After liver scan was performed by 3.0T MR scanner with 2D MFGRE sequence, the animals were sent for LIC assessment immediately. The R2* value were measured on R2* Map with whole liver and small region-of interest (ROI) selection by 2 observers, independently. The R2* value was compared between intra-and inter-observer; from the whole liver and the ROI, respectively.Results: The data from 2 types of measurement was consistent (P>0.05, ICC=0.99). The R2* value measured from the whole liver was smaller than that of ROI selection (P<0.05).Conclusion: To analyze the over-loaded liver by MRI R2*, the whole liver measurement is superior to the ROI positioning.
[Keywords] Region-of-interest；R2* value；Magnetic resonance imaging；Iron overload

HU Su Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

HU Chun-hong * Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

ZHANG Jing-gang Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

ZHANG Min-ge Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

WANG Fang-fang Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

XING jian-ming Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

CHEN jian-hua Imaging Center, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province 215006, P.R.China

*Correspondence to: Hu CH, E-mail: hch5305@163.com

Conflicts of interest   None.

Received  2011-10-26
Accepted  2011-12-11
DOI: 10.3969/j.issn.1674-8034.2012.01.011
DOI:10.3969/j.issn.1674-8034.2012.01.011.

[1]
Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J, 2001, 22(23): 2171-2179.
[2]
Papakonstantinou O, Alexopoulou E, Economopoulos N, et al. Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major. J Magn Reson Imaging, 2009, 29(4): 853-859.
[3]
Alustiza JM, Artetxe J, Castiella A, et al. MR quantification of hepatic iron concentration. Radiology, 2004, 230(2): 479-484.
[4]
Virtanen JM, Komu ME, Parkkola RK. Quantitative liver iron measurement by magnetic resonance imaging:in vitro and in vivo assessment of the liver to muscle signal intensity and the R2* methods. Magn Reson Imaging, 2008, 26(8): 1175-1182.
[5]
Christoforidis A, Perifanis V, Spanos G, et al. MRI assessment of liver iron content in thalassamic patients with three different protocols:comparisons and correlations. Eur J Haematol, 2009, 82(5): 388-392.
[6]
Ito K, Mitchell DG, Gabata T, et al. Hepatocellular carcinoma: association with increased iron deposition in the cirrhotic liver at MR imaging. Radiology, 1999, 212(1): 235-240.
[7]
Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood, 2005, 106(4): 1460-1465.
[8]
Song R, Cohen AR, Song HK. Improved transverse relaxation rate measurement techniques for the assessment of hepatic and myocardial iron content. J Magn Reson Imaging, 2007, 26(1): 208-214.
[9]
Positano V, Salani B, Pepe A, et al. Improved T2* assessment in liver iron overload by magnetic resonance imaging. Magn Reson Imaging, 2009, 27(2): 188-197.

PREV Study of magnetic resonance imaging at 1.5 Tesla based on pH-sensitive magnetization transfer technology
NEXT Placing a greater emphasis on anatomic structures of the brain
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn