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• Clinical Article •
Correlation investigate between grade of intratumoral susceptibility signals and relative quantitative of 1H-MRS in patients with brain astrocytic tumours
LIN Qi  ZHANG Qiang  CHEN Dong-ping  XU Kai-hua  CHEN Jin-yin 

DOI:10.3969/j.issn.1674-8034.2012.03.004.


[Abstract] Objective: To investigate the correlation between the grade of intratumoral susceptibility signals (ITSS) in high-resolution susceptibility-weighted imaging(SWI) and relative quantitative of multi-voxel 1H-MRS, and estimate its value on the grade of brain astrocytic tumours.Materials and Methods: The data of 33 patients with brain astrocytic tumours confirmed by postoperative pathologic were collected. Multi-voxel 1H-MRS calculates respectively the relative quantitative of Choline (Cho)/Creotine (Cr), Cho/N-acetylaspartate (NAA), and analyze with grade of ITSS correlation.Results: The high grade astrocytic tumours of ITSS classification was obviously higher than the low grade gliomas (P<0.01). The high grade astrocytic tumours of Cho/Cr, Cho/NAA relative quantitative ratio was obviously higher than the low grade astrocytic tumours (P<0.01). The higher the grade of ITSS was, the bigger the Cho/Cr, Cho/NAA of relative quantitative ratio was, which showed positive correlation (r=0.763, r=0.741, P<0.01).Conclusion: There is better positive correlation between grade of ITSS and relative quantitative of 1H-MRS in patients with brain astrocytic tumours. The grade of ITSS in brain astrocytic tumours can be used as classification diagnostic index.
[Keywords] Brain；Astrocytic tumour；Susceptibility weighted imaging；Magnetic resonance spectroscopy

LIN Qi * Department of radiology, First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

ZHANG Qiang Department of radiology, First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

CHEN Dong-ping Department of radiology, First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

XU Kai-hua Department of radiology, First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

CHEN Jin-yin Department of radiology, First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

*Correspondence to: Lin Q, E-amil: 2624403530@qq.com

Conflicts of interest   None.

Received  2011-12-28
Accepted  2012-02-20
DOI: 10.3969/j.issn.1674-8034.2012.03.004
DOI:10.3969/j.issn.1674-8034.2012.03.004.

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