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• Clinical Article •
3D MRI investigation on fetal surface malformations
PANG Ying  XIA Li-ming  SUN Zi-yan  CHEN Xin-lin  YANG Xiao-hong 

DOI:10.3969/j.issn.1674-8034.2012.03.008.


[Abstract] Objective: To investigate the clinical value of three dimensional magnetic resonance imaging (3D MRI) in displaying the normal and abnormal structures of fetal surface malformations.Materials and Methods: Thirty-four pregnant women were examined by conventional prenatal ultrasonography (US) and MRI, 36 fetus with surface malformations were conformed by follow-up results and autopsy. Single-shot fast spin-echo T2 weighted sequences (SSFSE) and thick-slab heavy T2WI with SSFSE were performed, 3D MRI with three dimensional fast image employing steady-state acquisition (3D FIESTA) were acquired. Volume rendering (VR), muti-planar reconstruction (MPR) and MR virtual endoscopy (MRVE) were employed in image post-processing on workstation. The results from 2D MR, 3D MRI and US images were compared with each other as well as the autopsy and follow-up results.Results: A total of 42 fetal surface malformations were identified by autopsy and follow-up after birth. 3D MRI was not affected by the complex superficial curvature changes, and could clearly demonstrate the surface features, and spatial positions of the fetus. The sensitivity, specificity, accuracy of 3D MRI/2D MRI/3D US were 90.48%/69.05%/95.12%, 100%/100%/99.81%, 99.31%/97.74%/99.48%. There were obvious statistical difference for sensitivity and accuracy of 2D MRI and 3D MRI, and unobvious statistical difference for sensitivity, specificity, and accuracy of 3D MRI and 3D US.Conclusion: 3D MRI is better than conventional 2D MRI in displaying fetal normal surface structure and malformations, and it has lager fov and higher soft tissue resolution than US. The 3D fetal MR imaging can be used as a complementary strategy to US in diagnosing fetal surface malformations.
[Keywords] Fetal diseases；Abnormalities；Magnetic resonsnce imaging；Ultrasonography, prenatal

PANG Ying Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

XIA Li-ming * Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

SUN Zi-yan Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

CHEN Xin-lin Department of Ultrasound, Hubei Maternal and Child Health Hospital, Wuhan 430070, China

YANG Xiao-hong Department of Ultrasound, Hubei Maternal and Child Health Hospital, Wuhan 430070, China

*Correspondence to: Xia LM, E-mail: xialiming88@yahoo.com.cn

Conflicts of interest   None.

Received  2011-08-28
Accepted  2012-02-27
DOI: 10.3969/j.issn.1674-8034.2012.03.008
DOI:10.3969/j.issn.1674-8034.2012.03.008.

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