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• Original Article •
Measurement of unilateral glomerular filtration rate with dynamic contrast-enhanced MRI in swine renal dysfunctional model
YE Lu  LI Qiong  LI Hong  DONG Feng  LIU Gui-bin  WANG Liang  LI Feng-tan  SUN Hao-ran 

DOI:10.3969/j.issn.1674-8034.2012.03.010.


[Abstract] Objective: To investigate the accuracy in estimating single kidney glomerular filtration rate (GFR) derived from low dose dynamic contrast-enhanced MR (MR Renography, MRR) and Patlak model in swine with unilateral renal arterial stenosis (RAS) and hydronephrosis on 3.0 T.Materials and Methods: In this animal care and use committee-approved study, RAS was surgically created in five pigs and hydronephrosis was surgically induced in another five pigs. Dynamic low-dose gadopentetate dimeglumine (0.04 mmol/kg) contrast enhanced MR imaging was performed in all ten pigs with a 3.0 T scanner. 99Tcm-DTPA scintigraphy soon afterwards provided reference standard of single-kidney GFR. Average signal intensities (SI) of region of interest on bilateral renal cortex were measured for each series, relative SI increments were calculated and the time-SI curves were plotted. Patlak model was used to analyze the aortic and renal cortical signal intensity vs. time curves (MRR) to obtain split GFRs. Values were reported as mean ± standard deviation (SD). GFRs measured with MRR were compared with the reference value from scintigraphy using Pearson’s correlation coefficient. The agreements between the two methods were assessed with the Bland-Altman plots and intraclass correlation coefficients (ICC), respectively.Results: Unilateral GFR from MR renography derived from Patlak model agreed well with reference measurements [(40.72±15.27) ml/min, 7.60-74.90 ml/min] in cortex regions [(39.60±12.42) ml/min, 7.62-66.40 ml/min)] (r =0.836, P= 0.000, n=20). Bland-Altman analysis showed that the average difference between GFRMR and reference values was-1.11 ml/min with a 95% confidence interval from-17.46 ml/min to 15.24 ml/min, of all 20 coupled GFRs, differences were within range of 95% confidence interval. The ICC value was 0.9508 (P<0.01). There statistical analysis showed there was a good consistence between GFRMR and standard reference.Conclusions: GFRs could be measured with low-dose MR renography and Patlak model, it has good consistence with standard reference from 99Tcm-DTPA scintigraphy.
[Keywords] Glomerular filtration rate；Renal artery obstruction；Hydronephrosis；Megnetic resonence imaging；Animals, laboratory

YE Lu Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China

LI Qiong Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Radiology, Tianjin Nankai Hospital, Tianjin 300100, China

LI Hong SINO-DUTCH Biomedical and Information Engineering school, Northeastern University, Shenyang 110819, China

DONG Feng Tianjin Medical University General Hospital, Tianjin 300052, China

LIU Gui-bin Tianjin Medical University General Hospital, Tianjin 300052, China

WANG Liang Tianjin Medical University General Hospital, Tianjin 300052, China

LI Feng-tan Tianjin Medical University General Hospital, Tianjin 300052, China

SUN Hao-ran * Tianjin Medical University General Hospital, Tianjin 300052, China

*Correspondence to: Sun HR, E-mail: sunhaoran2006@hotmail.com

Conflicts of interest   None.

Received  2012-03-05
Accepted  2012-03-23
DOI: 10.3969/j.issn.1674-8034.2012.03.010
DOI:10.3969/j.issn.1674-8034.2012.03.010.

[1]
Lee VS, Rusinek H, Johnson G, et al. MR renography with low-dose gadopetetate dimeglumine: feasibility. Radiology, 2001, 221(2): 371-379.
[2]
Erturk SM, Alberich-Bayarri A, Herrmann KA, et al. Use of 3.0-T MR Imaging for Evaluation of the Abdomen. Radiographics, 2009, 29(6): 1547-63.
[3]
Lee VS, Rusinek H, Noz M, et al. Dynamic three-dimensional MR renography for the measurement of single kidney function: initial experience. Radiology, 2003, 227(1): 289-294.
[4]
Mendichovszky I, Pedersen M, Frøkiaer J, et al. How accurate is dynamic contrast-enhanced MRI in the assessment of renal glomerular filtration rate? A critical appraisal. Magn Reson Imaging, 2008, 59(2): 278-288.
[5]
Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain barrier transfer constants from multiple time-uptake data. Cereb Blood Flow Metab, 1983, 3(1): 1-7.
[6]
Hackstein N, Heckrodt J, Rau WS. Measurement of single-kidney glomerular filtration rate using a contrast-enhanced dynamic gradient-echo sequence and the Rutland-Patlak plot technique. J Magn Reson Imaging, 2003, 18(6): 714-725.
[7]
Hackstein N, Puille MF, Benjamin HB, et al. Measurement of single kidney contrast media clearance by multiphasic spiral computed tomography: preliminary results. Eur J Radiol, 2001, 39(3): 201-208.
[8]
Rusinek H, Lee VS, Johnson G. Optimal dose of Gd-DTPA in dynamic MR studies. Magn Reson Med, 2001, 46(2): 312-316.
[9]
Grenier N, Mendichovszky I, de Senneville BD, et al. Measurement of glomerular filtration rate with magnetic resonance imaging: principles, limitations, and expectations. Semin Nucl Med, 2008, 38(1): 47-55.
[10]
Annet L, Hermoye L, Peeters F, et al. Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney. J Magn Reson Imaging, 2004, 20(3): 843-849.
[11]
Bokacheva L, Rusinek H, Zhang JL, et al. Estimates of glomerular filtration rate from mr renography and tracer kinetic models. J Magn Reson Imaging, 2009, 29(2): 371-382.
[12]
de Priester JA, den Boer JA, Giele EL, et al. MR renography: an algorithm for calculation and correction of cortical volume averaging in medullary renographs. J Magn Reson Imaging, 2000, 12(3): 453-459.
[13]
Hackstein N, Kooijman H, Tomaselli S, et al. Glomerular filtration rate measured using the Patlak plot technique and contrast-enhanced dynamic MRI with different amounts of gadolinium-DTPA. Magn Reson Imaging, 2005, 22(3): 406-414.
[14]
Buckley DL, Shurrab A, Cheung CM, et al. Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. Magn Reson Imaging. 2006, 24(5): 1117-1123.

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