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• Clinical Article •
3.0 T MRI T2-mapping evaluates knee cartilage degeneration
WANG He-xiang  HAO Da-peng  XU Wen-jian  LI Yu-jun  WANG Xiang-da  LIU Shi-en 

DOI:10.3969/j.issn.1674-8034.2012.04.002.


[Abstract] Objective: To explore the MRI value in diagnosing articular cartilage degeneration of knee joint by comparing MRI T2 value, T2-mapping appearances of tibial plateau cartilage degeneration with the corresponding pathological results.Materials and Methods: Eighteen of thirty-one knee joints undergone whole knee arthroplasty were chosen for MRI T2-mapping (T2 relaxation time) imaging. Ninety-eight cartilage subregions (specimens) were confirmed pathologically by a standard of Mankin’s pathological grade, The different degrees of histological degenerated cartilage were divided into five groups basing on Mankin's grading standard. All the T2 values were inputted the database and variance comparisons between groups were tested by One-Way ANOVA and LSD test to evaluate the ability of T2 value and T2-mapping artificial color image on displaying cartilage degeneration.Results: No statistical difference of T2 value was found between normal group [(32.28+ 4.15) ms] and grade Ⅱ [(34.42+5.76) ms] group, grade Ⅰ [(37.72+4.83) ms] and grade Ⅱ , grade Ⅲ [(41.63+6.10) ms] and grade Ⅳ [(45.98+7.32) ms] (P> 0.05) . Significant difference of T2 value was found between grade I and grade Ⅲ or grade Ⅳ, grade Ⅱ and grade Ⅲ or grade Ⅳ(P<0.05). Overall, T2 value could get increased significantly resulted from the severity of cartilage degeneration and the T2 value of grade Ⅱ group was slightly lower than that of grade I, but there was no statistical difference between grade Ⅱ group and normal group or grade I (P> 0.05). The signal change on T2-mapping artificial color image could sensitively display cartilage degeneration but hardly describe the degree of degeneration of cartilage.Conclusions: The T2 value of the articular cartilage could increase significantly with cartilage deterioration, which was highly related to the degree of cartilage degeneration and could be considered as a sensitive method to detect early cartilage degeneration.
[Keywords] Osteoarthrits；Knee；Cartilage；Magetic resonance imaging；Pathology

WANG He-xiang Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

HAO Da-peng Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

XU Wen-jian * Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

LI Yu-jun Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

WANG Xiang-da Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

LIU Shi-en Radiology Department, the Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China

*Correspondence to: Xu WJ, E-mail: cjr.xuwenjian@vip.163.com

Conflicts of interest   None.

Received  2012-05-28
Accepted  2012-06-19
DOI: 10.3969/j.issn.1674-8034.2012.04.002
DOI:10.3969/j.issn.1674-8034.2012.04.002.

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