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• Clinical Article •
A Meta analysis on apparent diffusion coefficient used to differentiate benign from malignant soft tissue tumors
LI Shu-jin  WU Xiao-bing  ZHANG Shao-wei  LIU Qi-wang  DAI Li-ping 

DOI:10.3969/j.issn.1674-8034.2012.04.004.


[Abstract] Objective: To evaluate diagnostic value of mean apparent diffusion coefficient (ADC)values depending on b value ranges on differentiating benign from malignant soft tissue tumors in diffusion-weighted imaging.Methods: A comprehensive search was conducted to screen out mean ADC values and SD values from included studies. Meta-analysis was applied with Medcalc software for calculation of standardized mean differences (SMD) of mean ADC values and 95% confidence intervals (CI) for SMD.Results: Ten studies were included in this Meta-analysis. B value ranged from 0 to 400 s/mm2 with a SMD (95% CI) of 0.86 (-0.46—2.19), 500 to 700 s/mm2 with that of 1.50 (0.79—2.21), and 800 to 1000 s/mm2 with that of 0.93 (0.40—1.46). There was no statistically significant difference in mean ADC values between benign and malignant soft tissue tumors when b value ranged from 0 to 400 s/mm2, and there were statistically significant differences when b value ranged from 500 to 700 s/mm2 and 800 to 1000 s/mm2, but SMD of the former exceeded that of the latter.Conclusions: ADC values in diffusion-weighted MRI maybe have more potential value in differentiating benign soft-tissue tumors from malignant ones when b value ranged from 500 to 700 s/mm2.
[Keywords] Magnetic resonance imaging；Diffusion weighted imaging；Soft tissue tumor；Meta analysis

LI Shu-jin * Changan Hospital of Dongguan City, Dongguan 523843, China

WU Xiao-bing Changan Hospital of Dongguan City, Dongguan 523843, China

ZHANG Shao-wei Changan Hospital of Dongguan City, Dongguan 523843, China

LIU Qi-wang Radiology Department of The First Hospital of Shanxi Medical University, Taiyuan 030000, China

DAI Li-ping Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China

*Correspondence to: Li SJ, E-mail: 13609670315@139.com

Conflicts of interest   None.

Received  2012-01-16
Accepted  2012-03-25
DOI: 10.3969/j.issn.1674-8034.2012.04.004
DOI:10.3969/j.issn.1674-8034.2012.04.004.

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