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• Clinical Article •
The application of MRI in the diagnosis and monitoring of treatment response in patients with polymyositis and dermatomyositis
HUANG Zhen-guo  YAN Ran  ZHANG Xue-zhe  WANG Li-wen  WANG Guo-chun  LU Xin  ZHANG Lu  WANG Wu 

DOI:10.3969/j.issn.1674-8034.2012.04.005.


[Abstract] Objective: To investigate the magnetic resonance imaging (MRI) findings of muscles and to assess the utility of MRI in the diagnosis and monitoring of treatment response in patients with polymyositis (PM) and dermatomyositis (DM).Materials and Methods: MR imagings were analysed retrospectively in 15 patients with PM and 21 patients with DM. MRI of thighs was performed for diagnostic purpose in all patients and during treatment the second MRI was underwent in 8 patients to monitor therapeutical effect. Fast spin echo T1-weighted, T2-weighted and short tau inversion recovery (STIR) sequences of bilateral thighs were obtained in all patients.Results: Among 36 patients with PM/DM, changes were detected in 31 patients on MRI. The findings included muscule edema in 30 patients, inflammation in fascia in 7 patients, edema in the subcutaneous tissue in 14, muscule distrophy followed fatty infiltration or replacement in 5. Inflammation absorbed partially or disappeared in all 8 patients who underwent MRI after treatment.Conclusion: MRI is a non-invasive, sensitive technique that is a powerful tool for diagnosis and monitoring of treatment response. Edema in muscle and subcutaneous tissue is the most common findings on MRI.
[Keywords] Polymyositis；Dermatomyositis；Magnetic resonance imaging

HUANG Zhen-guo Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

YAN Ran Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

ZHANG Xue-zhe Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

WANG Li-wen Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

WANG Guo-chun Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China

LU Xin Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China

ZHANG Lu Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China

WANG Wu * Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

*Correspondence to: Wang W, E-mail: wangwu@vip.163.com

Conflicts of interest   None.

Received  2012-06-12
Accepted  2012-06-29
DOI: 10.3969/j.issn.1674-8034.2012.04.005
DOI:10.3969/j.issn.1674-8034.2012.04.005.

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